Ian McKellen (Sherlock Holmes), Laura Linney (Mrs. Munro), Milo Parker (Roger), Hiroyuki Sanada (Tamiki Umezaki), Roger Allam (Dr. Barrie), Frances de la Tour (Madame Schirmer), Hattie Morahan (Ann Kelmot) more..., Phil Davis (Inspector Gilbert), Patrick Kennedy (Thomas Kelmot), John Sessions (Mycroft Holmes), Frances Barber (Matinee "Madame Schirmer"), Charles Maddox (Oswald), Takako Akashi (Maya Umezaki), Zak Shukor (Masuo Umezaki), Michael Culkin (Bank Manager), David Foxxe (Chemist), Oliver Devoti (Ticket Agent), Mike Burnside (Ann's Solicitor), Nicholas Rowe (Matinee "Sherlock Holmes"), Sam Coulson (Matinee "Thomas Kelmot"), Hermione Corfield (Matinee "Ann Kelmot"), Kit Connor (Boy), Zoe Rainey (Boy's Mother), Eileen Davies (Lady on Platform), Colin Starkey (Dr. John Watson), Sarah Crowden (Mrs. Hudson), Elizabeth Jane Cassidy (Waitress (uncredited)), John Carr (Patron in Cinema (uncredited)), Johnny Otto (Army Officer (uncredited)), Paul Blackwell (Station Passenger)

Carter Burwell (Original Music Composer), Paul Ritchie (Co-Producer), Martin Childs (Production Design), Tobias A. Schliessler (Director of Photography), Virginia Katz (Editor), Christine Langan (Executive Producer), Anne Carey (Producer) more..., Lucy Bevan (Casting), Arthur Conan Doyle (Characters), Konnie Daniel (Key Hair Stylist), Emile Sherman (Producer), Iain Canning (Producer), Zanne Devine (Executive Producer), Jeffrey Hatcher (Screenplay), Jay Peck (Foley), Mitch Cullin (Novel), Keith Madden (Costume Design), Lance Roehrig (First Assistant Director), Alexander Holt (Second Assistant Director), James Wakefield (Art Direction), Charlotte Dirickx (Set Decoration), Kate Glover (Unit Production Manager), Amy Nauiokas (Executive Producer), Greg Yolen (Co-Producer), Luca Borghese (Co-Producer), Renuka Ballal (Visual Effects Producer), John Bair (Visual Effects Supervisor), Michael Minkler (Sound Re-Recording Mixer), Sean Farrow (Visual Effects Supervisor), Jonathan Spencer (Gaffer), Marc Covington (Camera Operator), Kim Armitage (Script Supervisor), Paul Carter (Property Master), Dave Elsey (Hair Designer), Dave Elsey (Makeup Designer), John Diesso (Digital Intermediate), Jason Martin (Rigging Gaffer), Aviv Giladi (Executive Producer), Len Blavatnik (Executive Producer), Jonathan Houlding (Art Direction) and others.