Clint Eastwood (Blondie), Eli Wallach (Tuco Ramirez), Lee Van Cleef (Sentenza / Angel Eyes), Aldo Giuffrè (Alcoholic Union Captain), Luigi Pistilli (Father Pablo Ramirez), Rada Rassimov (Maria), Enzo Petito (Storekeeper) more..., Claudio Scarchilli (Tuco Henchman), Antonio Casale (Bill Carson / Jackson), Livio Lorenzon (Baker), Sandro Scarchilli (Tuco Henchman), Benito Stefanelli (Member of Angel Eyes' Gang), Angelo Novi (Monk), Antonio Casas (Stevens), Aldo Sambrell (Member of Angel Eyes' Gang), Al Mulock (One-Armed Bounty Hunter), Sergio Mendizábal (Blonde Bounty Hunter), Antonio Molino Rojo (Captain Harper), Lorenzo Robledo (Clem), Mario Brega (Corporal Wallace), Chelo Alonso (Stevens' Wife (uncredited)), Fortunato Arena (1st Sombrero Onlooker at Tuco's 1st Hanging (uncredited)), Román Ariznavarreta (Bounty Hunter (uncredited)), Silvana Bacci (Mexican Woman with Blondie (uncredited)), Joseph Bradley (Old Soldier (uncredited)), Frank Braña (Bounty Hunter #2 (uncredited)), Amerigo Castrighella (2nd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)), Saturno Cerra (Bounty Hunter (uncredited)), William Conroy (Confederate Soldier (uncredited)), Axel Darna (Dying Confederate Soldier (uncredited)), Tony Di Mitri (Deputy (uncredited)), Gianni Di Segni (Deputy at 1st Hanging (uncredited)), Alberigo Donadeo (Spectator Before Hanging (uncredited)), Attilio Dottesio (3rd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)), Luis Fernández de Eribe (Soldier Coat (uncredited)), Veriano Ginesi (Bald Onlooker at Tuco's 1st Hanging (uncredited)), Jesús Guzmán (Pardue the Hotel Owner (uncredited)), Víctor Israel (Sergeant at Confederate Fort (uncredited)), Nazzareno Natale (Mexican Bounty Hunter (uncredited)), Ricardo Palacios (Barista a Socorro (uncredited)) and others.

Gray Frederickson (Production Manager), Ennio Morricone (Original Music Composer), Tonino Delli Colli (Director of Photography), John Landis (Stunts), Sergio Leone (Screenplay), Sergio Leone (Story), Carlo Simi (Production Design) more..., Carlo Simi (Costume Design), Giovanni Corridori (Special Effects), Benito Stefanelli (Stunts), Benito Stefanelli (Stunt Coordinator), Nino Baragli (Editor), Eros Bacciucchi (Special Effects), Sergio Donati (Additional Dialogue), Luciano Vincenzoni (Screenplay), Luciano Vincenzoni (Story), Agenore Incrocci (Screenplay), Furio Scarpelli (Screenplay), Angelo Novi (Still Photographer), Alberto Grimaldi (Producer), Eugenio Alabiso (Editor), Fabio Testi (Stunts), Alessandro Alessandroni (Musician), Alessandro Alessandroni (Music Arranger), Bruno Nicolai (Music Director), Mickey Knox (Dialogue), Sergio Salvati (First Assistant Camera), Franco Di Giacomo (Camera Operator), Romano Puppo (Stunts), José Antonio Pérez Giner (Production Manager), Franco De Gemini (Musician), Giancarlo Santi (Assistant Director), Vittorio De Sisti (Sound Engineer), Román Ariznavarreta (Stunts), Carlo Leva (Assistant Art Director), Aldo Pomilia (Production Supervisor), Federico Tofi (Production Assistant), John O'Neill (Musician), Michele Lacerenza (Musician), Luigi Ciavarro (Stunts) and others.