Clint Eastwood (Blondie), Eli Wallach (Tuco Ramirez), Lee Van Cleef (Sentenza / Angel Eyes), Aldo Giuffrè (Alcoholic Union Captain), Luigi Pistilli (Father Pablo Ramirez), Rada Rassimov (Maria), Enzo Petito (Storekeeper) more..., Claudio Scarchilli (Tuco Henchman), Livio Lorenzon (Baker), Antonio Casale (Bill Carson / Jackson), Sandro Scarchilli (Tuco Henchman), Benito Stefanelli (Member of Angel Eyes' Gang), Angelo Novi (Monk), Mario Brega (Corporal Wallace), Al Mulock (One-Armed Bounty Hunter), Frank Braña (Bounty Hunter #2 (uncredited)), Saturno Cerra (Bounty Hunter #3 (uncredited)), Antonio Casas (Stevens (uncredited)), Chelo Alonso (Stevens' Wife (uncredited)), Antoñito Ruiz (Stevens' Youngest Son (uncredited)), John Bartha (Sheriff (uncredited)), Tony Di Mitri (Deputy (uncredited)), Attilio Dottesio (3rd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)), Amerigo Castrighella (2nd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)), Veriano Ginesi (Bald Onlooker at Tuco's 1st Hanging (uncredited)), Alberigo Donadeo (Spettatore Prima Impiccagione (uncredited)), Aysanoa Runachagua (Pistolero Recruited by Tuco in the Cave (uncredited)), Víctor Israel (Sergeant at Confederate Fort (uncredited)), José Terrón (Thomas 'Shorty' Larson (uncredited)), Román Ariznavarreta (Bounty Hunter (uncredited)), Antonio Molino Rojo (Captain Harper (uncredited)), Aldo Sambrell (Member of Angel Eyes' Gang (uncredited)), Romano Puppo (Bill - Member of Angel Eyes' Gang (uncredited)), Lorenzo Robledo (Clem - Member of Angel Eyes' Gang (uncredited)), Luigi Ciavarro (Slim - Member of Angel Eyes' Gang (uncredited)), Axel Darna (Soldato Confederato Morente (uncredited)), Richard Alagich (Soldato Unione all'Arresto (uncredited)), Fortunato Arena (1st Sombrero Onlooker at Tuco's 1st Hanging (uncredited)), Silvana Bacci (Messicana con Biondo (uncredited)), Joseph Bradley (Old Soldier (uncredited)) and others.

Gray Frederickson (Production Manager), Ennio Morricone (Original Music Composer), Tonino Delli Colli (Director of Photography), John Landis (Stunts), Sergio Leone (Screenplay), Sergio Leone (Story), Carlo Simi (Production Design) more..., Carlo Simi (Costume Design), Giovanni Corridori (Special Effects), Benito Stefanelli (Stunts), Benito Stefanelli (Stunt Coordinator), Nino Baragli (Editor), Eros Bacciucchi (Special Effects), Sergio Donati (Additional Dialogue), Luciano Vincenzoni (Screenplay), Luciano Vincenzoni (Story), Agenore Incrocci (Screenplay), Furio Scarpelli (Screenplay), Angelo Novi (Still Photographer), Alberto Grimaldi (Producer), Eugenio Alabiso (Editor), Fabio Testi (Stunts), Alessandro Alessandroni (Musician), Alessandro Alessandroni (Music Arranger), Bruno Nicolai (Music Director), Mickey Knox (Dialogue), Sergio Salvati (First Assistant Camera), Franco Di Giacomo (Camera Operator), Romano Puppo (Stunts), José Antonio Pérez Giner (Production Manager), Franco De Gemini (Musician), Giancarlo Santi (Assistant Director), Vittorio De Sisti (Sound Engineer), Román Ariznavarreta (Stunts), Carlo Leva (Assistant Art Director), Aldo Pomilia (Production Supervisor), Federico Tofi (Production Assistant), John O'Neill (Musician), Michele Lacerenza (Musician), Luigi Ciavarro (Stunts) and others.