Emma Thompson (Katherine Newbury), Mindy Kaling (Molly Patel), John Lithgow (Walter Newbury), Reid Scott (Tom Campbell), Hugh Dancy (Charlie Fain), Amy Ryan (Caroline Morton), Denis O'Hare (Brad) more..., Max Casella (Burditt), Paul Walter Hauser (Mancusco), John Early (Reynolds), Megalyn Echikunwoke (Robin), Luke Slattery (Hayes Campbell), Ike Barinholtz (Daniel Tennant), Marc Kudisch (Billy Katsner), Blake DeLong (McCary), Seth Meyers (Himself), Bill Maher (Himself), Annaleigh Ashford (Mimi Mismatch), Halston Sage (Zoe Martlin), David Neal Levin (Plant Manager), Maria Dizzia (Joan), Paige Gilbert (Dee), Kerry Flanagan (Female Reporter), Lucas Caleb Rooney (Gabe Eichler), Rupak Ginn (Teacher), Jake Tapper (Himself), Glo Tavarez (Young Woman), Sakina Jaffrey (Molly's Mom), Faith Logan (British Comedy Club Patron (uncredited))

Lesley Barber (Music), Howard Klein (Producer), Mindy Kaling (Producer), Mindy Kaling (Writer), Ben Browning (Producer), Elizabeth J. Jones (Production Design), Maribeth Fox (Casting) more..., David Rogers (Editor), Eleanor Infante (Editor), Laura Rosenthal (Casting), Linda Cohen (Music Supervisor), Erika Hampson (Co-Producer), Matthew Clark (Director of Photography), Jillian Apfelbaum (Producer), Mitchell Travers (Costume Designer), Milan Popelka (Executive Producer), Daniel Steinman (Executive Producer), Micah Green (Executive Producer), Alison Cohen (Executive Producer),