Millie Bobby Brown (Enola Holmes), Henry Cavill (Sherlock Holmes), Sam Claflin (Mycroft Holmes), Helena Bonham Carter (Eudoria Holmes), Louis Partridge (Lord Tewkesbury), Adeel Akhtar (Lestrade), Fiona Shaw (Miss Harrison) more..., Frances de la Tour (The Dowager), Burn Gorman (Linthorn), Susan Wokoma (Edith), Claire Rushbrook (Mrs. Lane), David Bamber (Sir Whimbrel), Hattie Morahan (Lady Tewkesbury), Gaby French (Seamstress), Paul Copley (Station Master), Ellie Haddington (Miss Gregory), Alex Kelly (Miss Gregory II), James Duke (Footman), Connor Catchpole (Gardener), Sarah Flind (Tea Shop Assistant), Dempsey Bovell (Fleet Street Hawker), Neil Bell (Constable), Sofia Stavrinou (Young Enola), Sophie Dixon (Toddler Enola), David Kirkbride (Agitator), Delroy Atkinson (Porter), Mary Roscoe (Grace Whitting), Anthony Aje (Newspaper Boy (House of Lords)), Anthony Rickman (Newspaper Boy (Fleet Street)), Philip Scott-Wallace (Newspaper Editor), Tuyen Do (Boarding School Teacher), Esther Coles (Miss Fox), Owen Atlas (Young Sherlock Holmes (uncredited)), Gianni Calchetti (Roy (uncredited)), Paul Parker (Police Inspector (uncredited)), Heather Pearse (Hawker (uncredited)), Jay Simpson (Conductor (uncredited))

Jina Jay (Casting), Consolata Boyle (Costume Design), Michael Carlin (Production Design), Michael Dreyer (Executive Producer), Jack Thorne (Screenplay), Millie Bobby Brown (Producer), Adam Bosman (Editor) more..., Nancy Springer (Novel), Paige Brown (Producer), Giles Nuttgens (Director of Photography), Michael Dreyer (Unit Production Manager), Alex Garcia (Producer), Mary Parent (Producer), Harry Bradbeer (Executive Producer), Daniel Pemberton (Original Music Composer), Simon Fraser (Unit Production Manager), Jo McLaren (Stunt Coordinator), Jane Houston (Co-Producer), Ali Mendes (Producer), Jack Ravenscroft (First Assistant Director), Joe Barlow (Second Assistant Director), Joshua Grode (Executive Producer), Kim McGarrity (Stunts), Giles Nuttgens ("A" Camera Operator), Tom Sayers (Sound Designer), Peter Afterman (Music Supervisor), Martin Hitchcock (Art Direction), Paul Edwards (Steadicam Operator), Paul Edwards ("B" Camera Operator), Lisa Chugg (Set Decoration), Samir Foco (Sound Designer), Sav Akyüz (Storyboard Artist), Mark Holt (Special Effects Supervisor), Nina Armstrong (Stunts), Sue Harding (Foley Artist), Alex Bailey (Still Photographer), Luke Scott (Stunts), Emma Zee (Post Production Supervisor), Marion Weise (Costume Supervisor), Carol Hemming (Hairstylist) and others.