Ryan Reynolds (Guy), Jodie Comer (Millie Rusk / Molotov Girl), Lil Rel Howery (Buddy), Joe Keery (Walter 'Keys' McKeys), Taika Waititi (Antwan), Utkarsh Ambudkar (Mouser), Owen Burke (Bank Robber #2) more..., Kayla Caulfield (Soonami Tech), Camille Kostek (Bombshell), Michael Malvesti (Newsstand Man), Cassidy Neal (NPC - Police Officer), Ryan Doyle (Teen Boy #3), David Morwick (Douche Guy), David Arthur Sousa (Homeless Man), Britne Oldford (Missy), Seán McLoughlin (Jacksepticeye), Imane Anys (Pokimane), Lannan Eacott (Lazarbeam), Matthew Cardarople (Keith, the 22-Year-Old Gamer), Leah Procito (Bank Teller), Sophie Levy (Big City Dreamer), Brandon Scales (Businessman NPC), Michael Tow (Rain Man), Kayla Rae Vesce (Soldier Avatar), Ian Wallace (Video Game Reporter), Ninja (Ninja), Alex Trebek (Alex Trebek), Aaron W Reed (Dude), Mark Lainer (Hostage), Naheem Garcia (Convenience Store Owner Joe), Anabel Graetz (Cat Lady Phyllis), Vernon Scott (Bank Manager), Mike Devine (Officer Johnny), Ric Plamenco (Ice Cream Vendor), Kenneth Israel (Businessman), Colin Allen (Shoe Store Clerk), Hugh Jackman (Masked Player in Alley (voice)), Dwayne Johnson (Bank Robber #2 (voice)), Tina Fey (Vacuuming Mom (voice)), John Krasinski (Silhouetted Gamer (voice)) and others.

Marlene Stewart (Costume Design), Beat Frutiger (Supervising Art Director), Leslie E. Rollins (Set Decoration), Josh McLaglen (First Assistant Director), Shawn Levy (Producer), Ryan Reynolds (Producer), Greg Berlanti (Producer) more..., Matt Lieberman (Screenplay), Freddy Bouciegues (Fight Choreographer), Ethan Tobman (Production Design), Steve Cooper (Art Direction), Maurice K. McGuire (Camera Operator), Sarah Schechter (Producer), Alan Markfield (Still Photographer), Mark Fitzgerald (Location Manager), John Ruggieri (Pyrotechnician), Eric Swanek (First Assistant "A" Camera), Brandon Beckman (Stunt Driver), Daniel Stevens (Stunt Double), Joseph Battista (Grip), Tom Williams (Sound Mixer), Matt Magnolia (Visual Effects Coordinator), Greg Wimer (First Assistant "B" Camera), Tyler Swanek (Loader), Joel Reidy (Boom Operator), Robert McKinnon (Concept Artist), Douglas Cowell (Extras Casting Coordinator), Stephanie Portnoy Porter (Assistant Costume Designer), Adam Peabody (Electrician), Jennifer LaFace (Propmaker), Charles Cooley (Special Effects Technician), Jyothi Kalyan Sura (Visual Effects Art Director), Lori Gomes (Hair Setup), Christopher Conroy (Set Dresser), Isaac Nadreau (Stage Director), Kelly Walton (Props), Nico Coucke (Stunts), George Dewey (Executive Producer), Carolina Jiménez (Layout), Josh McLaglen (Executive Producer) and others.