Ryan Reynolds (Guy), Jodie Comer (Millie Rusk / Molotovgirl), Joe Keery (Walter 'Keys' McKeys), Lil Rel Howery (Buddy), Utkarsh Ambudkar (Mouser), Taika Waititi (Antwan Hovachelik), Channing Tatum (Revenjamin Buttons) more..., Aaron W Reed (Dude), Britne Oldford (Barista), Camille Kostek (Bombshell), Mark Lainer (Hostage), Mike Devine (Officer Johnny), Sophie Levy (Big City Dreamer), Vernon Scott (Bank Manager), Naheem Garcia (Convenience Store Owner Joe), Anabel Graetz (Cat Lady Phyllis), Ric Plamenco (Ice Cream Vendor), Kenneth Israel (Businessman), Michael Malvesti (Newsstand Vendor), Colin Allen (Shoe Store Clerk), Michael Tow (Rain Man), Hugh Jackman (Masked Player in Alley (voice)), Dwayne Johnson (Bank Robber #2 (voice)), Tina Fey (Vacuuming Mom (voice)), John Krasinski (Silhouetted Gamer (voice)), Chris Evans (Chris Evans), Alex Trebek (Alex Trebek), Lara Spencer (Lara Spencer), Matthew Cardarople (Keith, the 22-Year-Old Gamer), Jonathan De Azevedo (Jonathan), Destiny Claymore (Art Nerd), Ninja (Ninja), Pokimane (Pokimane), Lannan Eacott (Lazarbeam), Seán McLoughlin (Jacksepticeye), DanTDM (DanTDM), Charlotte Levy (Tween Gamer Girl), Colette Levy (Foul-Mouthed Little Sister), Mariama Conde (Teenage Girl), Olivia Z. Cote (Teenage Girl) and others.

Marlene Stewart (Costume Design), Beat Frutiger (Supervising Art Director), Leslie E. Rollins (Set Decoration), Josh McLaglen (First Assistant Director), Shawn Levy (Producer), Ryan Reynolds (Producer), Greg Berlanti (Producer) more..., Matt Lieberman (Screenplay), Freddy Bouciegues (Fight Choreographer), Ethan Tobman (Production Design), Steve Cooper (Art Direction), Maurice K. McGuire (Camera Operator), Sarah Schechter (Producer), Alan Markfield (Still Photographer), Mark Fitzgerald (Location Manager), John Ruggieri (Pyrotechnician), Eric Swanek (First Assistant "A" Camera), Brandon Beckman (Stunt Driver), Daniel Stevens (Stunt Double), Joseph Battista (Grip), Tom Williams (Sound Mixer), Matt Magnolia (Visual Effects Coordinator), Greg Wimer (First Assistant "B" Camera), Tyler Swanek (Loader), Joel Reidy (Boom Operator), Robert McKinnon (Concept Artist), Douglas Cowell (Extras Casting Coordinator), Stephanie Portnoy Porter (Assistant Costume Designer), Adam Peabody (Electrician), Jennifer LaFace (Propmaker), Charles Cooley (Special Effects Technician), Jyothi Kalyan Sura (Visual Effects Art Director), Lori Gomes (Hair Setup), Christopher Conroy (Set Dresser), Isaac Nadreau (Stage Director), Kelly Walton (Props), Nico Coucke (Stunts), George Dewey (Executive Producer), Carolina Jiménez (Layout), Josh McLaglen (Executive Producer) and others.