Audrey Tautou (Amélie Poulain), Mathieu Kassovitz (Nino Quincampoix), Rufus (Raphaël Poulain), Serge Merlin (Raymond Dufayel), Jamel Debbouze (Lucien), Clotilde Mollet (Gina), Claire Maurier (Suzanne) more..., Isabelle Nanty (Georgette), Dominique Pinon (Joseph), Artus de Penguern (Hipolito), Yolande Moreau (Madeleine Wallace), Urbain Cancelier (Collignon), Lorella Cravotta (Amandine Poulain), Maurice Bénichou (Dominique Bretodeau), Michel Robin (Mr. Collignon), Andrée Damant (Mrs. Collignon), Claude Perron (Eva), Armelle (Philomène), Ticky Holgado (Man in Photo), André Dussollier (Narrator (voice)), Eugène Berthier (Eugène Koler), Charles-Roger Bour (Man with Pissoir), Kevin Dias (Young Dominique), Flora Guiet (Young Amélie), Amaury Babault (Young Nino), Marion Pressburger (Small Hands), Luc Palun (Amandine's Grocer), Fabienne Chaudat (Woman in Coma), Dominique Bettenfeld (Amélie's Neighbor), Jacques Viala (Client Humiliating Friend), Fabien Béhar (Humiliated Friend), Jonathan Joss (Humiliated Friend's Son), Jean-Pierre Becker (Homeless Man), Jean Darie (Blind Man), Thierry Gibault (Endive Client), François Bercovici (Endive Client's Friend), Franck Monier (Young Dominique), Guillaume Viry (SDF), Valérie Zarrouk (Dominique's Wife), Marie-Laure Descoureaux (Concierge of the Dead) and others.

Claudie Ossard (Producer), Arne Meerkamp van Embden (Producer), Bruno Delbonnel (Director of Photography), Pierre-Jacques Bénichou (Casting), Hervé Schneid (Editor), Guillaume Laurant (Dialogue), Helmut Breuer (Co-Producer) more..., Yann Tiersen (Original Music Composer), Aline Bonetto (Production Design), Volker Schäfer (Art Direction), Madeline Fontaine (Costume Design), Rémi Canaple (Stunts Coordinator), Patrick Cauderlier (Stunts), Frédéric Mitterrand (Thanks), Anne Wermelinger (Script Supervisor), Jacques Pélissier (Art Department Assistant), Daniel Kolarov (Assistant Art Director), Stefan Quentin (Construction Coordinator), Aude Lemercier (Location Scout), Dominique Colin (Camera Operator), Matthieu Bastid (First Assistant Camera), Jörg Widmer (Steadicam Operator), Bruno Calvo (Still Photographer), Emma Lebail (Assistant Costume Designer), Véronique Boitout (Hairstylist), John Nollet (Key Hair Stylist), Reiner Brüggen (Carpenter), Werner Ahrendt (Driver), Sophie Vermersch (Post Production Supervisor), Séverine De Wever (Special Effects Coordinator), Victor Abadia (Electrician), Michel Sabourdy (Gaffer), Valérie Espagne (Casting Associate), Wendy K. Hope (Production Coordinator), Jean-Louis Lebras (Boom Operator), Jean-Michel Tresallet (Foley), Hervé Schneid (Music Editor), Gérard Hardy (Sound Editor), Jean-Pierre Lelong (Sound Effects Editor), Vincent Arnardi (Sound Re-Recording Mixer) and others.