Virginie Efira (Sœur Benedetta Carlini), Charlotte Rampling (Soeur Felicita, l'abbesse), Daphné Patakia (Bartolomea), Lambert Wilson (Alfonso, le Nonce-messager), Olivier Rabourdin (Alfonso Cecchi) more..., Louise Chevillotte (Sœur Christina), Hervé Pierre (Paolo Ricordati), Clotilde Courau (Midea Carlini, la mère de Benedetta), David Clavel (Giuliano Carlini, le père de Benedetta), Guilaine Londez (Soeur Jacopa), Justine Bachelet (Sœur Juliana), Lauriane Riquet (Sœur Roasanna), Eléna Plonka (Benedetta enfant), Héloïse Bresc (Christina enfant), Jonathan Couzinié (Jésus-Christ), Vinciane Millereau (La doctoresse), Jérôme Chappatte (Le secrétaire), Ewan Ribard (Le bourreau), Nicolas Béguinot (Le scribe), Satya Dusaugey (Le mercenaire Dragon), Nicolas Gaspar (Le capitaine des mercenaires), Benjamin Penemaria (Le capitaine des soldats), Antoine Lelandais (Le lieutenant), Frédéric Sauzay (Le Berger), Sophie Breyer (La novice), Célia Kaci (La jeune novice), Alexia Chardard (Sœur Giulia), Sébastien Chabane (Un badaud), Boris Gillot (Le marchand), Léa Lopez (L'adolescente de Pescia n°1), Olga Milshtein (L'adolescente de Pescia n°2), Pascal Le Corre (Un flagellant), Raphaël Potier (Une victime de la peste), Philippe Saunier (Un habitant de Pescia), Fabrice Cals (Un habitant de la ville), Quentin D'Hainaut (Un villageois) and others.

Paul Verhoeven (Screenplay), Saïd Ben Saïd (Producer), Jérôme Seydoux (Producer), Job ter Burg (Editor), David Birke (Screenplay), Michel Merkt (Producer), Jeanne Lapoirie (Director of Photography) more..., Anne Dudley (Original Music Composer), Jean-Paul Mugel (Sound Mixer), Katia Wyszkop (Production Design), Pierre-Jean Larroque (Costume Design), Eric Bourges (Art Direction), Stéphane Batut (Casting), Katia Boutin (Dialogue Editor), Katia Boutin (ADR Supervisor), Philippe Penot (Foley Artist), Cyril Holtz (Sound Re-Recording Mixer), Damien Lazzerini (Sound Re-Recording Mixer), Florian Penot (Assistant Foley Artist), Damien Luquet (Boom Operator), Alexis Place (Sound Supervisor), Charles de Ville (Sound Editor), Margot Saada (ADR Editor), Jules Laurin (Foley Editor), Antoine Citrinot (Assistant Sound Editor), Conchita Airoldi (Executive Producer), Frans van Gestel (Co-Producer), Alain Carsoux (Visual Effects Director), Teun Hilte (Co-Producer), Job ter Burg (Associate Producer), Arnold Heslenfeld (Co-Producer), Guillaume Le Gouez (Visual Effects Supervisor), Laurette Schillings (Co-Producer), Kevin Chneiweiss (Associate Producer), Marion Frelat (Visual Effects Coordinator), Fabrice Delville (Co-Producer), Christophe Toulemonde (Co-Producer), Patrick Vandenbosch (Co-Producer), Kateryna Merkt (Associate Producer), Ayelen Camiña (Visual Effects Coordinator) and others.