Tom Holland (Nathan Drake), Mark Wahlberg (Victor 'Sully' Sullivan), Sophia Ali (Chloe Frazer), Tati Gabrielle (Jo Braddock), Antonio Banderas (Santiago Moncada), Steven Waddington (The Scotsman), Rudy Pankow (Young Sam) more..., Tiernan Jones (Young Nate), Pingi Moli (Hugo), Jesús Evita (Guard at Museum), Georgia Goodman (Sister Bernadette), Diarmaid Murtagh (Police Officer), Joseph Balderrama (Carlos), Serena Posadino (Goldie), Alana Boden (Zoe), Jonathan Failla (Unsuspecting Doorman), Anthony Thomas (Luxury Sedan Driver), Peter Seaton-Clark (Auctioneer), Robert Maaser (Guard at Auction), Eskindir Tesfay (Security Guard), Manuel de Blas (Armando Moncada), Carme Capdet (Spanish Nun), Julia Schunevitsch (Club Bartender #1), Alois Knapps (Club Bartender #2), Patricia Meeden (Spanish Woman in Club), Nolan North (Hotel Guest), Matt Barkley (Hotel Bellman), Jimmy Hart (Concepcion Helo Pilot), Brett Praed (Concepcion Co-Pilot), Carlo Kitzlinger (Trinidad Helo PIlot), Pilou Asbæk (Gage), Rubén Doblas Gundersen (Young Man (uncredited))

Charles Roven (Producer), Shepherd Frankel (Production Design), Avi Arad (Producer), Jeong Jeong-hun (Director of Photography), Cornelia Ott (Art Direction), Elli Griff (Set Decoration), Art Marcum (Screenplay) more..., Art Marcum (Executive Producer), Matt Holloway (Screenplay), Matt Holloway (Executive Producer), Alex Gartner (Producer), Ruben Fleischer (Executive Producer), Allan A. Apone (Makeup Artist), Ari Arad (Producer), Nenad Pečur (Art Direction), Carter Swan (Executive Producer), Tom Holland (Executive Producer), Rafe Judkins (Screenplay), David Bernad (Executive Producer), Daniel Chour (Art Direction), Neil Druckmann (Executive Producer), Michael Fissneider (Art Direction), Clay Enos (Still Photographer), Stefan Speth (Art Direction), Bob Dohrmann (Executive Producer), Florian Müller (Art Direction), Calla Klessig (Art Direction), Evan Wells (Executive Producer), Asad Qizilbash (Executive Producer), Mathias Datow (Assistant Director), David Ingram (Supervising Art Director), Manfred Banach (Sound Mixer), Kami Asgar (Supervising Sound Editor), Mark DeSimone (ADR Mixer), Beau Borders (Sound Re-Recording Mixer), Erin Oakley (Supervising Sound Editor), Adam De Coster (Foley Artist), Matt Cavanaugh (Sound Effects Editor), Nebojša Tabački (Set Designer), Thomas Elder-Groebe (Visual Effects Producer) and others.