Noah Wyle (John Carter), Goran Višnjić (Luka Kovač), Maura Tierney (Abby Lockhart), Anthony Edwards (Mark Greene), Mekhi Phifer (Greg Pratt), Sherry Stringfield (Susan Lewis), Alex Kingston (Elizabeth Corday) more..., Parminder Nagra (Neela Rasgotra), Linda Cardellini (Samantha Taggart), Shane West (Ray Barnett), Julianna Margulies (Carol Hathaway), Laura Innes (Kerry Weaver), Ming-Na Wen (Jing-Mei Chen), Scott Grimes (Archie Morris), Sharif Atkins (Michael Gallant), Paul McCrane (Robert Romano), David Lyons (Simon Brenner), Michael Michele (Cleo Finch), Angela Bassett (Catherine Banfield), Erik Palladino (Dave Malucci), George Clooney (Dr. Doug Ross), Kellie Martin (Lucy Knight), Eriq La Salle (Peter Benton), Maria Bello (Anna Del Amico), George Clooney (Doug Ross), Gloria Reuben (Jeanie Boulet), John Stamos (Tony Gates), Lester G. Reynolds (Crash Victim)

Lisa Zwerling (Co-Executive Producer), Dieter Ismagil (Associate Producer), David Malloy (Associate Producer), Christopher Chulack (Executive Producer), Christopher Misiano (Producer), Patrick Harbinson (Producer), John Wells (Executive Producer) more..., Lydia Woodward (Co-Executive Producer), Carol Flint (Co-Executive Producer), Neal Baer (Co-Producer), Christopher Chulack (Consulting Producer), Neal Baer (Co-Executive Producer), R. Scott Gemmill (Supervising Producer), Jack Orman (Co-Executive Producer), Julie Hébert (Supervising Producer), Tommy Burns (Co-Producer), Yahlin Chang (Co-Producer), R. Scott Gemmill (Executive Producer), Jonathan Kaplan (Co-Executive Producer), Joe Sachs (Supervising Producer), Lisa Zwerling (Supervising Producer), Virgil Williams (Supervising Producer), Janine Sherman Barrois (Executive Producer), Joe Sachs (Executive Producer), Tommy Burns (Producer), David Zabel (Executive Producer), Wendy Spence (Producer), Michael Crichton (Executive Producer), Christopher Chulack (Producer), Lance Gentile (Co-Producer), Paul Manning (Supervising Producer), Wendy Spence (Co-Producer), Lydia Woodward (Executive Producer), Christopher Chulack (Co-Executive Producer), Jack Orman (Co-Producer), Neal Baer (Producer), Lance Gentile (Producer), Walon Green (Co-Executive Producer), David Mills (Co-Producer), Carol Flint (Executive Producer) and others.