Chevy Chase (Clark Griswold), Beverly D'Angelo (Ellen Griswold), Anthony Michael Hall (Rusty Griswold), Imogene Coca (Aunt Edna), Randy Quaid (Cousin Eddie), Dana Barron (Audrey Griswold), Eddie Bracken (Roy Walley) more..., Brian Doyle-Murray (Kamp Komfort Clerk), Miriam Flynn (Cousin Catherine), James Keach (Motorcycle Cop), Eugene Levy (Car Salesman), Frank McRae (Grover), John Candy (Lasky, Guard at Walleyworld), Christie Brinkley (Girl In The Red Ferrari), Jane Krakowski (Cousin Vicki), John P. Navin, Jr. (Cousin Dale), Nathan Cook (Man Giving Directions), Christopher Jackson (Pimp), Mickey Jones (Mechanic), John Diehl (Assistant Mechanic), Jeannie Dimter Barton (Dodge City Cashier), Randy Lowell (Wyatt Earp), Virgil Wyaco II (Indian), Gerry Black (Davenport), James Staley (Motel Desk Clerk), Adelaide Wilder (Car Hop), Tessa Richarde (Motel Guest), Fritz Ford (Neighbor), Eric Stacey (Neighbor), Scott Perry (Swat Leader), Dennis Freeman (Policeman), Michael Talbott (Cowboy), John Craigmile (Camel Rider), Henry Gibson (Hotel clerk (uncredited)), Harold Ramis (Car salesman (voice) (uncredited))

John Hughes (Screenplay), Matty Simmons (Producer), Victor J. Kemper (Director of Photography), Ralph Burns (Original Music Composer), Pembroke J. Herring (Editor), Sam Mercer (Location Manager), Phyllis Huffman (Casting) more..., Bub Asman (Sound Editor), Jack T. Collis (Production Design), Susan Arnold (Casting), Joe D. Mitchell (Set Decoration), Frank Griffin (Makeup Artist), Wayne Fitzgerald (Title Designer), Robert M. Stevens (Camera Operator), Martin Raymond Bolger (Sound Mixer), Lindsey Buckingham (Songs), Lindsey Buckingham (Vocals), Alan Greedy (Script Supervisor), Robert J. Visciglia Sr. (Property Master), Dick Ziker (Stunt Coordinator), John M. Woodward (Transportation Coordinator), Paul Vombrack (Second Unit Director of Photography), Tim Board (Assistant Editor), Adele Taylor (Hairstylist), Alan Robert Murray (Sound Editor), Earl Gilbert (Gaffer), Robert G. Henderson (Sound Editor), Elliott Marks (Still Photographer), Eugene Marks (Music Editor), Kevin Jewison (Second Assistant Camera), Hal Whitby (Boom Operator), Caryl Wickman (Dialogue Editor), Robert P. Cohen (First Assistant Director), Robert Grand (Unit Production Manager), Robert Grand (Associate Producer), Patrick Marshall (Rigging Gaffer), Earl Clark (Assistant Camera), Donah Bassett (Negative Cutter), Bernie Schwartz (Dolly Grip), Brooke Henderson Ward (Assistant Sound Editor) and others.