Robert Downey Jr. (Sherlock Holmes), Jude Law (Dr. John Watson), Rachel McAdams (Irene Adler), Mark Strong (Lord Blackwood), Eddie Marsan (Inspector Lestrade), Robert Maillet (Dredger), Geraldine James (Mrs. Hudson) more..., Kelly Reilly (Mary), William Houston (Constable Clark), Hans Matheson (Lord Coward), James Fox (Sir Thomas Rotheram), William Hope (Ambassador Standish), Clive Russell (Captain Tanner), Oran Gurel (Reordan), David Garrick (McMurdo), Ky Discala (Maid), Andrew Brooke (Guard Captain), John Kearney (Carriage Driver), Sebastian Abineri (Coach Driver), Jonathan Gabriel Robbins (Guard), James A. Stephens (Captain Philips), Terence Taplin (Groundskeeper), Bronagh Gallagher (Palm Reader), Ed Tolputt (Anonymous Man), Joe Egan (Big Man), Jefferson Hall (Young Guard), Miles Jupp (Waiter), Marn Davies (Police Officer), Andrew Greenough (Prison Guard), Ned Dennehy (Man with Roses), Martin Ewens (Removable Man), Amanda Grace Johnson (Young Woman Sacrifice), James Greene (Governor), David Emmings (Grave Policeman), Chris Sunley (Grave Policeman), Michael Jenn (Preacher), Timothy O'Hara (Porter / Smith), Guy Williams (Golden Dawn Envoy), Peter Miles (Thug), Jonathan Bridge (Man Carrying Tray of Fish in Market (uncredited)) and others.

Anthony Peckham (Screenplay), Simon Kinberg (Screenplay), Lionel Wigram (Screenstory), Michael Robert Johnson (Screenstory), Arthur Conan Doyle (Characters), Hans Zimmer (Music), Bruce Berman (Executive Producer) more..., Michael Tadross (Executive Producer), Dana Goldberg (Executive Producer), Susan Downey (Producer), Dan Lin (Producer), Joel Silver (Producer), Lionel Wigram (Producer), Peter Eskelsen (Producer), Steve Clark-Hall (Producer), Michael Robert Johnson (Screenplay), James Herbert (Editor), Philippe Rousselot (Director of Photography), Sarah Greenwood (Production Design), Jenny Beavan (Costume Design), Reg Poerscout-Edgerton (Casting), Alex Bailey (Still Photographer), Katie Spencer (Set Decoration), Kevin Kaska (Orchestrator), James Foster (Art Direction), Nick Gottschalk (Art Direction), Matthew Gray (Art Direction), Niall Moroney (Supervising Art Director), Christine Blundell (Hair Designer), Carol 'Ci Ci' Campbell (Hairstylist), Charmaine Fuller (Hairstylist), Chloe Meddings (Hairstylist), Paul Mooney (Hairstylist), Lesa Warrener (Hairstylist), Julia Wilson (Hairstylist), Patricia Regan (Makeup Artist), Lesa Warrener (Makeup Artist), Julia Wilson (Makeup Artist), Christine Blundell (Makeup Designer), Des Whelan (Camera Operator) and others.