Tobey Maguire (Homer Wells), Charlize Theron (Candy Kendall), Michael Caine (Dr. Wilbur Larch), Delroy Lindo (Arthur Rose), Paul Rudd (Lt. Wally Worthington), Jane Alexander (Nurse Edna), Kathy Baker (Nurse Angela) more..., Erykah Badu (Rose Rose), Kieran Culkin (Buster), Kate Nelligan (Olive Worthington), Heavy D (Peaches), J.K. Simmons (Ray Kendall), Erik Per Sullivan (Fuzzy), Paz de la Huerta (Mary Agnes), K. Todd Freeman (Muddy), Evan Parke (Jack), Jimmy Flynn (Vernon), Lonnie Farmer (Hero), Spencer Diamond (Curly), Skye McCole Bartusiak (Hazel), Sean Andrew (Copperfield), John Albano (Steerforth), Claire Daly (Clara), Colin Irving (Major Winslow), Annie Corley (Carla), Patrick Donnelly (Adopting Father), Edie Schechter (Adopting Mother), Kasey Berry (12yr. Old Girl), Mary Bogue (Big Dot), Victoria Stankiewicz (Debra), Christine Stevens (Florence), Earle C. Batchelder (Dr. Holtz), Norma Fine (Mrs. Goodhall), John Irving (Stationmaster), Eric Bruno Borgman (Flirting Soldier on Train (uncredited)), Kevin Chapman (Adopting Dad (uncredited)), John H. Tobin (Man on Train (uncredited))

John Irving (Novel), John Irving (Screenplay), Alan C. Blomquist (Producer), Bobby Cohen (Executive Producer), Leslie Holleran (Producer), Richard N. Gladstein (Producer), Meryl Poster (Executive Producer) more..., Bob Weinstein (Executive Producer), Harvey Weinstein (Executive Producer), Lila Yacoub (Producer), Oliver Stapleton (Director of Photography), Lisa Zeno Churgin (Editor), Kerry Barden (Casting), Billy Hopkins (Casting), Suzanne Smith Crowley (Casting), David Gropman (Production Design), Karen Schulz Gropman (Art Direction), Beth A. Rubino (Set Decoration), Renee Ehrlich Kalfus (Costume Design), Sharyn Cordice (Makeup Artist), Brenda McNally (Hairstylist), Peggy Schierholz (Hairstylist), Ellie Winslow (Makeup Artist), Barbara A. Hall (Unit Production Manager), Katia Milani (Post Production Supervisor), Diana Zock (Production Supervisor), Wylie Griffin (Art Department Coordinator), Ron Bolanowski (Special Effects Coordinator), Jane Goldsmith (Script Supervisor), Michele Platt (Associate Producer), Charles Croughwell (Stunt Coordinator), Denney Pierce (Utility Stunts), Wayne Herndon (Hairstylist), Deborah K. Larsen (Makeup Artist), Louie Zakarian (Makeup Artist), Stephen P. Dunn (First Assistant Director), Paul Prenderville (Second Second Assistant Director), Christina Stauffer (Second Assistant Director), Paul Prenderville (First Assistant Director), Robert Bolanowski (Special Effects) and others.