Cailey Fleming (Bea), Ryan Reynolds (Cal), John Krasinski (Dad / Marshmallow (voice)), Fiona Shaw (Grandmother), Steve Carell (Blue (voice)), Phoebe Waller-Bridge (Blossom (voice)), Louis Gossett Jr. (Lewis (voice)) more..., Alan Kim (Benjamin), Liza Colón-Zayas (Janet), Bobby Moynihan (Jeremy), Catharine Daddario (Bea’s Mom), Audrey Hoffman (Bea (Ages 3 & 5)), Laquet Sharnell Pringle (Receptionist), Ed Herbstman (Deli Guy), Barbara Andres (Woman Upstairs), Alexander Rivero (Custodian), Shauna Pinkett (Hospital Receptionist), Sa'Raya Paris Johnson (7 Year-Old Girl), Marta Siteiya Moipei (Coffee Shop Barista), David Weissmann (Young Jeremy), Awkwafina (Bubble (voice)), Emily Blunt (Unicorn (voice)), George Clooney (Spaceman (voice)), Bradley Cooper (Ice (voice)), Matt Damon (Flower (voice)), Bill Hader (Banana (voice)), Richard Jenkins (Art Teacher (voice)), Keegan-Michael Key (Slime (voice)), Blake Lively (Octopuss (voice)), Sebastian Maniscalco (Magician Mouse (voice)), Christopher Meloni (Cosmo (voice)), Matthew Rhys (Ghost (voice)), Sam Rockwell (Guardian Dog (voice)), Maya Rudolph (Alligator (voice)), Amy Schumer (Gummy Bear (voice)), Allyson Seeger (Viola (voice)), Jon Stewart (Robot (voice)), Craig 'Radio Man' Castaldo (Radio Man (uncredited))

Janusz Kamiński (Director of Photography), John Krasinski (Producer), John Krasinski (Writer), Ryan Reynolds (Producer), Andrew Form (Producer), Allyson Seeger (Producer), George Dewey (Executive Producer) more..., Michael Giacchino (Original Music Composer), Christopher Rouse (Editor), Andy Canny (Editor), John J. Kelly (Executive Producer), Jess Gonchor (Production Design), Louis Gossett Jr. (In Memory Of), Tricia Wood (Casting), Jennifer L. Smith (Casting), Mandy Moore (Choreographer), Alexa Ginsburg (Co-Producer), Kimberly Nelson LoCascio (Executive Producer), Jess Kidd (Co-Producer), Michael Lerman (Co-Producer), Jenny Eagan (Costume Design), Arslan Elver (Animation Supervisor), Chris Lawrence (Visual Effects Supervisor), Michael Lerman (First Assistant Director), Woodrow Travers (Second Assistant Director), Randy Manion (Unit Production Manager), John J. Kelly (Unit Production Manager), Mark Pettograsso (Stunt Coordinator), Kyle Woods (Stunt Coordinator), Mike Gunther (Stunt Coordinator), James Mather (Supervising Sound Editor), Mike Prestwood Smith (Sound Re-Recording Mixer), Mark Taylor (Sound Re-Recording Mixer), Brandon Proctor (Sound Re-Recording Mixer), Lee Salevan (Sound Re-Recording Mixer), Ethan Van der Ryn (Supervising Sound Editor), Erik Aadahl (Supervising Sound Editor), Jeff Robinson (Associate Producer), Lori Scowley (Associate Producer), Lori Scowley (Production Controller) and others.