Keanu Reeves (John Wick), Common (Cassian), Ian McShane (Winston), Laurence Fishburne (Bowery King), Riccardo Scamarcio (Santino D'Antonio), Ruby Rose (Ares), Lance Reddick (Charon) more..., Peter Stormare (Abram Tarasov), Bridget Moynahan (Helen Wick), Franco Nero (Julius), John Leguizamo (Aurelio), Claudia Gerini (Gianna D'Antonio), Wass Stevens (Consiglieri), Peter Serafinowicz (Sommelier), Luca Mosca (Italian Tailor), Tobias Segal (Earl), Thomas Sadoski (Jimmy), Chukwudi Iwuji (Mr. Akoni), Yama (Sumo Assassin (uncredited)), Erik Frandsen (Numismatic), David Patrick Kelly (Charlie), Perry Yung (Dr. Randall), Youma Diakite (Lucia), Midori Nakamura (Seamstress), Mario Donatone (Cardinal), Giorgio Carminati (Priest), Elli (Pawnbroker), Thaddeus Daniels (Nigerian Man), Margaret Daly (The Operator), Christine Hollingsworth (Bartender), Ciscandra Nostalghia (Concert Singer), Vadim Kroll (Cheslav), Simone Spinazzè (Cartographer), Chris LaPanta (Earl's Guard #1), Guyviaud Joseph (Earl's Guard #2), Diane Gooch (Waitress), Alisa Ermolaev (Switchboard Operator #1), Kelly Rae LeGault (Switchboard Operator #2), Joan Smalls (Continental Female Assassin), Basil Iwanyk Sr. (Creepy Homeless Man) and others.

Evan Schiff (Editor), Kevin Kavanaugh (Production Design), Saverio Sammali (Art Direction), Chris Shriver (Art Direction), Luca Mosca (Costume Design), Letizia Santucci (Set Decoration), Jessica Kelly (Casting) more..., Suzanne Crowley (Casting), Robert Bernacchi (Executive Producer), Kevin Scott Frakes (Executive Producer), Basil Iwanyk (Producer), David Leitch (Executive Producer), Jennifer Madeloff (Associate Producer), Marco Valerio Pugini (Line Producer), Vishal Rungta (Executive Producer), Holly S. Rymon (Co-Producer), Chad Stahelski (Executive Producer), Jeff G. Waxman (Executive Producer), David Schlesinger (Set Decoration), Christian Giuliani (Art Department Coordinator), Sha-Sha Shiau (Art Department Coordinator), James Wendelken (Construction Coordinator), Kate Geller (Casting Associate), Eddie Grisco (Armorer), Shane B. Scott (Script Supervisor), Richard Henderson (Music Editor), Jen Monnar (Music Editor), John Houlihan (Music Supervisor), Brian Hemesath (Assistant Costume Designer), Jill Flowers (Costume Supervisor), Augusto Grassi (Costume Supervisor), Erick Martinez (Costume Supervisor), Alessia Pierantoni (Costume Coordinator), Carmia Marshall (Key Costumer), Paul Thompson (Key Costumer), Costanza Bastanti (Set Costumer), Zakiya Dennis (Set Costumer), Carmegie Dupuy (Set Costumer), Eldar Iskandarov (Set Costumer), Carlotta Moricci (Set Costumer) and others.