Tom Holland (Peter Parker / Spider-Man), Zendaya (MJ), Mark Ruffalo (Bruce Banner / Hulk), Jon Bernthal (Frank Castle / Punisher), Jacob Batalon (Ned Leeds), Sadie Sink (Jean Grey), Florence Pugh (Yelena Belova / Black Widow) more..., Liza Colón-Zayas (Detective Jean DeWolff), Tramell Tillman (William 'Bill' Metzger), Marisa Tomei (May Parker), Naomi Watts (E.V. (voice)), Michael Mando (Mac Gargan / Scorpion), Keith David (Narrator of Spider Video (voice)), Marvin Jones III (Tombstone), Olivia Booth-Ford (Sara), Taryn Marie Butler (Apartment Girl), Johnny Myers (Building Manager), Billy Clements (Ramrod), Zabryna Guevara (Sheila Rivera), Nina Rose Galano (Marley), Maikol Roque (EJ), Jamel Davall Rodriguez (NYC Street Driver), Ethan Sokontwe (Scooter Kid), Tariyé Peterside (Tour Bus Guide), Phoenix Di Sebastiani (DODC Escort Guard), Vivien Keene (Female Janitor), Kurtis Lowe (DODC Box Guard), Marc Small (DODC Box Agent), David Hepple (Warehouse Worker), Jamaal Burcher (DODC Crew Chief), Lieve Carchon (Bathhouse Attendant), Mary Stillwaggon Stewart (Female DODC Guard), Luka Hays (DODC Weapons Tech), Camila López (Bodega Clerk), Robert Veng (Partygoer), Aoife Haakenson (Partygoer), Gabriel Blaikie (Partygoer), Eman Esfandi (The Boyfriend), Shing Moussa Chung (Building Tenant), Akil Young (Apartment Girl Boyfriend) and others.

Kevin Feige (Producer), Amy Pascal (Producer), Louis D'Esposito (Executive Producer), Stan Lee (Comic Book), Sarah Halley Finn (Casting), Steve Ditko (Characters), Stan Lee (Characters) more..., Steve Ditko (Comic Book), Erik Sommers (Writer), Chris McKenna (Writer), Peng Zhang (Stunt Coordinator), Peng Zhang (Second Unit Director), Jonathan Spencer (Gaffer), Alistair Williams (Special Effects Supervisor), Dave Jordan (Music Supervisor), Tracey Wilson (Storyboard Artist), Brett Pawlak (Director of Photography), Robert Consing (Storyboard Artist), Nat Sanders (Editor), Jo Beckett (Script Supervisor), Michael Giacchino (Original Music Composer), Karsten Bloch Jacobsen ("A" Camera Operator), Karsten Bloch Jacobsen (Steadicam Operator), Luke Scott (Stunt Double), Sanja Milkovic Hays (Costume Design), Simon Finney ("B" Camera Operator), Leonard Woodcock (Stunt Coordinator), Charles Wood (Production Design), Boris Martinez (Stunts), Steve Ellingworth (Key Grip), John Casali (Production Sound Mixer), Xiang-Yang Xu (Fight Choreographer), Arron Monkman (First Assistant "A" Camera), Alessandro Bertolazzi (Hair Designer), Alessandro Bertolazzi (Makeup Designer), Peter Hayley-Barker (Best Boy Grip), Jacob Barrie (First Assistant "B" Camera), Rachel O'Connor (Producer), John Bush (Set Decoration), Miguel Pariente (Production Accountant) and others.