Benedict Cumberbatch (Dr. Stephen Strange), Chiwetel Ejiofor (Mordo), Rachel McAdams (Dr. Christine Palmer), Benedict Wong (Wong), Mads Mikkelsen (Kaecilius), Tilda Swinton (The Ancient One), Michael Stuhlbarg (Dr. Nicodemus West) more..., Benjamin Bratt (Jonathan Pangborn), Scott Adkins (Lucian / Strong Zealot), Zara Phythian (Brunette Zealot), Alaa Safi (Tall Zealot), Katrina Durden (Blonde Zealot), Topo Wresniwiro (Hamir), Umit Ulgen (Sol Rama), Linda Louise Duan (Tina Minoru), Mark Anthony Brighton (Daniel Drumm), Meera Syal (Dr. Patel), Amy Landecker (Dr. Bruner), Adam Pelta-Pauls (Nurse Billy), Sarah Malin (Dr. Garrison), Eben Young (Dr. Weiss), Kobna Holdbrook-Smith (Physical Therapist), Elizabeth Healey (Concerned Doctor), Guillaume Faure (Reluctant Surgeon), Daniel Dow (Mugger), Stan Lee (Bus Passenger), Ezra Faroque Khan (Kamar-Taj Librarian), Kimberly Van Luin (Bullet Patient's Wife), Pat Kiernan (Pat Kiernan), Raj Awasti (Street Passerby (uncredited)), Jill Buchanan (Physio Patient (uncredited)), Daniel Eghan (Hospital Visitor (uncredited)), Juani Feliz (Girl on the Bus (uncredited)), Mo Idriss (New York Pedestrian (uncredited)), Tamika Katon-Donegal (Assistant (uncredited)), Pezh Maan (Doctor (uncredited)), Kei Miura (Hong Kong Officer (uncredited)), Cameron Moon (Sadhu (uncredited)), Emeson Nwolie (Man in Street (uncredited)), Clem So (Kamar-Taj Disciple (uncredited)) and others.

Hunter Elliott (Visual Effects Coordinator), Hank Amos (Utility Stunts), Nick Brandon (Utility Stunts), James M. Churchman (Stunt Coordinator), Gui DaSilva-Greene (Stunt Double), Colin Follenweider (Utility Stunts), Dom Dumaresq (Stunts) more..., Tim Gallin (Stunt Coordinator), Thomas Robinson Harper (Stunt Coordinator), Paul Leonard (Utility Stunts), Ginger McCarthy (Stunts), Sarah Molasky (Stunt Double), Mark Mottram (Stunt Coordinator), Tsuyoshi Abe (Stunt Double), Nina Armstrong (Stunts), Wendy Armstrong (Stunts), Katy Bullock (Stunts), Blaise Corrigan (Stunts), Chris Barnes (Stunts), Nicole Callender (Stunts), Kachina Dechert (Stunts), Christoph Cordell (Stunts), Roy Farfel (Stunts), Tracey Eddon (Stunts), Peter Epstein (Stunts), Zoli Dora (Utility Stunts), Jeff Habberstad (Stunts), Shane Habberstad (Stunts), Cort Hessler (Stunt Driver), Trevor Habberstad (Stunt Double), George Kirby (Stunt Double), Jennifer Lamb (Stunts), Tomasz Krzemieniecki (Stunt Double), Casey Michaels (Stunts), Joanna Shelmidine (Stunts), Jodi Michelle Pynn (Stunts), Gary Tacon (Stunts), Myke Schwartz (Stunts), Leo Woodruff (Stunt Double), Patrick M. Walsh (Stunts) and others.