Meryl Streep (Miranda Priestly), Anne Hathaway (Andy Sachs), Emily Blunt (Emily), Stanley Tucci (Nigel), Simon Baker (Christian Thompson), Adrian Grenier (Nate), Tracie Thoms (Lily) more..., Rich Sommer (Doug), Daniel Sunjata (James Holt), David Marshall Grant (Richard Sachs), James Naughton (Stephen), Tibor Feldman (Irv Ravitz), Rebecca Mader (Jocelyn), Jimena Hoyos (Lucia), Gisele Bündchen (Serena), George C. Wolfe (Paul), John Rothman (Editor), Stephanie Szostak (Jacqueline Follet), Colleen Dengel (Caroline), Suzanne Dengel (Cassidy), Heidi Klum (Heidi Klum), Valentino (Valentino Garavani), Bridget Hall (Bridget Hall), Ines Rivero (Clacker in Elevator), Alyssa Sutherland (Clacker), Robert Verdi (Fashion Reporter), Paul Keany (St. Regis Butler), David Callegati (Massimo), Rori Cannon (Girl at Party), Stan Newman (John Folger), James Cronin (Ambassador), Eric Seltzer (Roy), Lindsay Brice (PR Woman), Steve Benisty (Fashion Photographer), John Graham (Book Guy), Wells Dixon (Miranda's Driver), Ilona Alexandra (Red Carpet Celebrity (uncredited)), Frank Anello (Security (uncredited)), Alexander Blaise (French Bellhop (uncredited)), Carl Burrows (Businessman (uncredited)) and others.

Aline Brosh McKenna (Screenplay), Wendy Finerman (Producer), Karen Rosenfelt (Executive Producer), Joseph M. Caracciolo Jr. (Executive Producer), John Bernard (Line Producer), Theodore Shapiro (Original Music Composer), Florian Ballhaus (Director of Photography) more..., Mark Livolsi (Editor), Ellen Lewis (Casting), Jess Gonchor (Production Design), Anne Seibel (Art Direction), Tom Warren (Art Direction), Lydia Marks (Set Decoration), John A. Machione (Unit Production Manager), Judy Richter (Unit Production Manager), Lauren Weisberger (Novel), Amanda Pollack (First Assistant Editor), Andrew Weisblum (Main Title Designer), T.J. O'Mara (Production Sound Mixer), Michel Kharat (Production Sound Mixer), J. Roy Helland (Makeup & Hair), Wyatt Sprague (Sound Effects Editor), Nicholas Renbeck (Supervising Sound Editor), George A. Lara (Foley Mixer), Nicki Ledermann (Key Makeup Artist), Stephen Lee Davis (First Assistant Director), Maya Hardinge (Makeup Artist), Evelyne Noraz (Makeup Artist), Tom Fleischman (Sound Re-Recording Mixer), Kenton Jakub (ADR Editor), Allan Zaleski (Sound Effects Editor), Angel De Angelis (Key Hair Stylist), Branka Mrkic (Dialogue Editor), Paul Urmson (Supervising Sound Editor), Dan Paikin (Boom Operator), Igor Nikolic (Foley Editor), Rick Chefalas (Assistant Sound Editor), Steven Visscher (Foley Supervisor), Ali Cherkaoui (First Assistant Director), Lidia Tamplenizza (Apprentice Sound Editor) and others.