Meryl Streep (Miranda Priestly), Anne Hathaway (Andy Sachs), Emily Blunt (Emily), Stanley Tucci (Nigel), Simon Baker (Christian Thompson), Adrian Grenier (Nate), Tracie Thoms (Lily) more..., Rich Sommer (Doug), Daniel Sunjata (James Holt), David Marshall Grant (Richard Sachs), James Naughton (Stephen), Tibor Feldman (Irv Ravitz), Rebecca Mader (Jocelyn), Jimena Hoyos (Lucia), Gisele Bündchen (Serena), George C. Wolfe (Paul), John Rothman (Editor), Stephanie Szostak (Jacqueline Follet), Colleen Dengel (Caroline), Suzanne Dengel (Cassidy), Heidi Klum (Self), Valentino Garavani (Self), Bridget Hall (Self), Ines Rivero (Clacker in Elevator), Alyssa Sutherland (Clacker), Robert Verdi (Fashion Reporter), Paul Keany (St. Regis Butler), David Callegati (Massimo), Rori Cannon (Girl at Party), Stan Newman (John Folger), James Cronin (Ambassador), Eric Seltzer (Roy), Lindsay Brice (PR Woman), Steve Benisty (Fashion Photographer), John Graham (Book Guy), Wells Dixon (Miranda's Driver), Ilona Alexandra (Red Carpet Celebrity (uncredited)), Frank Anello (Security (uncredited)), Alexander Blaise (French Bellhop (uncredited)), Marie Brandt (Fashion Show Attendee (uncredited)) and others.

Aline Brosh McKenna (Screenplay), Wendy Finerman (Producer), Karen Rosenfelt (Executive Producer), Joseph M. Caracciolo Jr. (Executive Producer), John Bernard (Line Producer), Theodore Shapiro (Original Music Composer), Florian Ballhaus (Director of Photography) more..., Mark Livolsi (Editor), Ellen Lewis (Casting), Jess Gonchor (Production Design), Anne Seibel (Art Direction), Tom Warren (Art Direction), Lydia Marks (Set Decoration), Patricia Field (Costume Design), John A. Machione (Unit Production Manager), Judy Richter (Unit Production Manager), Lauren Weisberger (Novel), Amanda Pollack (First Assistant Editor),