Dwayne Johnson (Dr. Xander 'Smolder' Bravestone), Kevin Hart (Franklin 'Mouse' Finbar), Jack Black (Professor Sheldon 'Shelly' Oberon), Karen Gillan (Ruby Roundhouse), Rhys Darby (Nigel Billingsley), Bobby Cannavale (Van Pelt), Nick Jonas (Jefferson 'Seaplane' McDonough) more..., Alex Wolff (Spencer Gilpin), Ser'Darius Blain (Anthony 'Fridge' Johnson), Madison Iseman (Bethany Walker), Morgan Turner (Martha Kaply), Sean Buxton (Jogger), Mason Guccione (Gamer), Marin Hinkle (Spencer's Mom), Tracey Bonner (Fridge's Mom), Najah Jackson (Girl in Car), Natasha Charles Parker (Bethany's Mom), Kat Altman (Lucinda), Maribeth Monroe (Teacher), Missi Pyle (Coach Webb), Michael Shacket (Fussfeld), Jamie Renell (Male Gym Teacher), Marc Evan Jackson (Principal Bentley), Carlease Burke (Miss Mathers), Colin Hanks (Alex Vreeke), Jason New (Bivouac Biker), Rohan Chand (Kid at Bazaar), William Tokarsky (Bread Vendor), Tait Fletcher (Scorpion Recipient), Stephen Dunlevy (Transportation Shed Guard), Rob Mars (Transportation Shed Guard), Virginia Newcomb (Alex's Wife (uncredited)), Sylvia Jefferies (Jogger's Wife (uncredited)), Daniel Salyers (High School Student (uncredited)), Tim Matheson (Old Man Vreeke (uncredited)), Tad Sallee (Skater Punk (uncredited)), Ryan Baughman (Boy #1 (uncredited)), Maddie Nichols (Kid #2 (uncredited)), Ashley Lonardo (Kid #3 (uncredited)), Friday Chamberlain (Amazon Warrior (uncredited)) and others.

William Teitler (Producer), Matt Tolmach (Producer), Melvin Mar (Co-Producer), Hiram Garcia (Co-Producer), Ted Field (Executive Producer), Dany Garcia (Executive Producer), David B. Householter (Executive Producer) more..., Dwayne Johnson (Executive Producer), Jake Kasdan (Executive Producer), Mike Weber (Executive Producer), Henry Jackman (Original Music Composer), Gyula Pados (Director of Photography), Chris McKenna (Screenplay), Erik Sommers (Screenplay), Scott Rosenberg (Screenplay), Jeff Pinkner (Screenplay), Chris McKenna (Screenstory), Chris Van Allsburg (Book), Steve Edwards (Editor), Mark Helfrich (Editor), Nicole Abellara Hallman (Casting), Jeanne McCarthy (Casting), Steve Cooper (Art Direction), Hugo Santiago (Art Direction), Ronald R. Reiss (Set Decoration), Yani Lathouris (Visual Effects), Jerome Chen (Visual Effects Supervisor), Paul Schneider (Second Assistant Director), Stella Vaccaro (Set Designer), David B. Householter (Unit Production Manager), Jussi Tegelman (Sound Editor), Basil Grillo (Unit Production Manager), Matt Rebenkoff (First Assistant Director), Gary Hymes (Stunt Coordinator), David Nelson (Visual Effects Supervisor), Julian Slater (Sound Designer), Julian Slater (Supervising Sound Editor), Julian Slater (Sound Re-Recording Mixer), Toni G (Makeup Department Head), Julia Frey (Visual Effects Producer) and others.