Cate Blanchett (Daisy Fuller), Brad Pitt (Benjamin Button), Tilda Swinton (Elizabeth Abbott), Julia Ormond (Caroline Fuller), Elle Fanning (Daisy Age 7), Madisen Beaty (Daisy Age 10), Jason Flemyng (Thomas Button) more..., Elias Koteas (Monsieur Gateau), Taraji P. Henson (Queenie), Josh Stewart (Pleasant Curtis), Faune A. Chambers (Dorothy Baker), Donna DuPlantier (Blanche Devereux), Jacob Tolano (Martin Gateau), Ed Metzger (Teddy Roosevelt), Danny Vinson (Priest Giving Last Rites), David Jensen (Doctor at Benjamin's Birth), Joeanna Sayler (Caroline Button), Rus Blackwell (Robert Williams), Mahershala Ali (Tizzy Weathers), Adrian Armas (David), Phyllis Somerville (Grandma Fuller), Lance E. Nichols (Preacher), David Ross Paterson (Walter Abbott), Fiona Hale (Mrs. Hollister), Marion Zinser (Mrs. Horton), Edith Ivey (Mrs. Maple), Patrick Thomas O'Brien (Dr. Rose), Ted Manson (Mr. Daws), Clay Cullen (Young Mr. Daws), Peter Donald Badalamenti II (Benjamin 1928-31), Paula Gray (Sybil Wagner), Jared Harris (Captain Mike), Earl Maddox (Man at Train Station), Bianca Chiminello (Ballerina Who Ties Up Shoelace (uncredited)), Emma Degerstedt (Ballet Dancer (uncredited)), Megan Brown (Woman Kissing Benjamin (uncredited)), Clay Chamberlin (The Grumpy Sailor (uncredited)), Chandler Canterbury (Benjamin Age 8)

F. Scott Fitzgerald (Novel), Eric Roth (Screenplay), Ceán Chaffin (Producer), Kathleen Kennedy (Producer), Frank Marshall (Producer), Laray Mayfield (Casting), Jacqueline West (Costume Design) more..., Kirk Baxter (Editor), Angus Wall (Editor), Donald Graham Burt (Production Design), Kelly Curley (Art Direction), Michele Laliberte (Art Direction), Randy Moore (Art Direction), Scott Plauche (Art Direction), Victor J. Zolfo (Set Decoration), Colleen Callaghan (Hairstylist), John Jack Curtin (Hairstylist), Beatrice De Alba (Hairstylist), Susan V. Kalinowski (Hairstylist), Yolanda Mercadel (Hairstylist), Donita Miller (Hairstylist), Donna Spahn (Hairstylist), Jean Ann Black (Makeup Department Head), Jessica Anderson Crocker (Makeup Artist), Fionagh Cush (Makeup Artist), Elaine L. Offers (Makeup Artist), Paige Reeves (Makeup Artist), Diane Simard (Makeup Artist), Christopher Dooly (Makeup Effects), Chris Gallaher (Makeup Effects), Will Huff (Makeup Effects), Brian A. Jones (Makeup Effects), Mark Nieman (Makeup Effects), Alexei O'Brien (Makeup Effects), Art Pimentel (Makeup Effects), Marie Régimbald (Makeup Effects), Kazuhiro Tsuji (Makeup Effects), Natasha Ladek (Wigmaker), Marc A. Hammer (Production Supervisor), Lisa D. DiSanto (Art Department Coordinator) and others.