Tom Cruise (Roy Miller), Cameron Diaz (June Havens), Peter Sarsgaard (Fitzgerald), Viola Davis (CIA Director Isabel George), Jordi Mollà (Antonio Quintana), Paul Dano (Simon Feck), Maggie Grace (April Havens) more..., Marc Blucas (Rodney), Celia Weston (Molly Knight), Dale Dye (Frank Knight), Falk Hentschel (Bernhard), Lennie Loftin (Braces), Rich Manley (Danny), Gal Gadot (Naomi), Jack O'Connell (Wilmer), Trevor Loomis (Eduardo), Nilaja Sun (Allison), Jerrell Lee Wesley (Fireman Paul), Adam Gregor (Train Cook), Ronn Surels (Flight Attendant), Arnold Chon (Gunman with Shotgun (uncredited))

Patrick O'Neill (Writer), Phedon Papamichael (Director of Photography), Arnon Milchan (Executive Producer), Joe Roth (Executive Producer), Steve Pink (Producer), José Luis Escolar (Line Producer), Todd Garner (Producer) more..., Cathy Konrad (Producer), Quincy Z. Gunderson (Editor), Michael McCusker (Editor), Andrew Menzies (Production Design), Donna DeSeta (Casting), Sarah Katzman (Casting), Lisa Beach (Casting), Jeffrey Wisniewski (Art Direction), Jay Hart (Set Decoration), Arianne Phillips (Costume Design), Wendy Means (Art Department Coordinator), Michael Meinardus (Special Effects Coordinator), Regina Cachuela (Animation Director), Taylor Carrasco (Animation Director), Chad Shattuck (Animation Supervisor), Ivy Agregan (Visual Effects Coordinator), Janet Muswell (Visual Effects Producer), Maurice K. McGuire (Camera Operator), Rafael E. Sánchez (Gaffer), Gary Dahlquist (Rigging Gaffer), Frank Masi (Still Photographer), David James (Still Photographer), Trevor Loomis (First Assistant Camera), Philip Shanahan (First Assistant Camera), Kyle Thomas Coker (Casting Associate), Jeremy Gordon (Casting Associate), Beth Lipari (Casting Associate), Robert Q. Mathews (Costume Supervisor), Rosa J. Colón (Set Costumer), Tom Cummins (Set Costumer), Guillaume DeLouche (Armorer), Kathrine Gordon (Hair Department Head), Kristen Barry (Key Hair Stylist) and others.