Katherine Heigl (Jane Nichols), James Marsden (Kevin Doyle), Malin Åkerman (Tess Nichols), Judy Greer (Casey), Edward Burns (George), Melora Hardin (Maureen), Brian Kerwin (Hal Nichols) more..., Maulik Pancholy (Trent), David Castro (Pedro), Krysten Ritter (Gina the Goth), Michael Ziegfeld (Taxi Fahrer Khaleel), Jennifer Lim (Bridal Salesgirl), Danielle Skraastad (Bride Suzanne), Yetta Gottesman (Hip Bridesmaid), Erin Fogel (Shari Rabinowitz), Bern Cohen (Rabbi), Brigitte Bourdeau (Salesgirl Olga), Peyton List (Young Jane), Charli Barcena (Young Tess), Jane Pfitsch (Cousin Lisa), Laksh Singh (Hindu Priest), Lyralen Kaye (Yoga Instructor), Ronald Guttman (Antoine), Ron Simons (Boathouse Chef), Robert Clohessy (Dive Bartender), Michael Mosley (Bar Dude), Alyssa Bresnahan (Diner Waitress), Ellen H. Schwartz (Diner Waitress), Jennifer Bassey (Jane's Aunt), Alexa Havins (Boat Bride), Richard O'Rourke (Jane's Minister), Kathryn Weisbeck (Tara Bride (uncredited))

Roger Birnbaum (Producer), Gary Barber (Producer), Jonathan Glickman (Producer), Becki Cross Trujillo (Executive Producer), Michael Mayer (Executive Producer), Erin Stam (Executive Producer), Peter James (Director of Photography) more..., Priscilla Nedd-Friendly (Editor), Catherine Marie Thomas (Costume Design), Robert F. Newmyer (Executive Producer), Steven Feinberg (Thanks), Zachary Woodlee (Choreographer), Ray Fisher (Leadman), Aline Brosh McKenna (Writer), Shepherd Frankel (Production Design), Buck Damon (Music Supervisor), Cathy Sandrich Gelfond (Casting), Amanda Mackey (Casting), Steph Accetta (Unit Production Manager), Adam McCarthy (Production Supervisor), Steven Ritzi (Stunt Coordinator), Jonathan Arkin (Art Direction), Miguel López-Castillo (Art Direction), Chryss Hionis (Set Decoration), Jason Mayoh (Art Department Coordinator), Barry Wetcher (Still Photographer), Tom Nelson (Production Sound Mixer), Frank Graziadei (Boom Operator), Deborah Newhall (Costume Supervisor), Linda Grimes (Makeup Department Head), Anthony Veader (Hair Department Head), Susanna David (Script Supervisor), Adam McCarthy (Location Manager), Peter Oillataguerre (Executive In Charge Of Production), Jocelyn Thomas (Casting Associate), Kate Bulpitt (Casting Associate), Joseph Kearney (Construction Coordinator), Michael Atwell (Construction Foreman), Amanda Goodpaster (Music Editor), Charles Martin Inouye (Music Editor) and others.