Ellen Burstyn (Sara Goldfarb), Jared Leto (Harry Goldfarb), Jennifer Connelly (Marion Silver), Marlon Wayans (Tyrone C. Love), Christopher McDonald (Tappy Tibbons), Louise Lasser (Ada), Marcia Jean Kurtz (Rae) more..., Janet Sarno (Mrs. Pearlman), Suzanne Shepherd (Mrs. Scarlini), Joanne Gordon (Mrs. Ovadia), Charlotte Aronofsky (Mrs. Miles), Mark Margolis (Mr. Rabinowitz), Michael Kaycheck (Donut Cop), Peter Maloney (Dr. Pill), Denise Dowse (Tyrone's Mother), Olga Merediz (Malin & Block Secretary), Ben Shenkman (Dr. Spencer), Keith David (Big Tim), Dylan Baker (Southern Doctor), Bill Buell (Court Doctor), Lianna Pai (Angelic Nurse), Stanley B. Herman (Uncle Hank), Gregg Bello (E.R. Doctor), Shaun O'Hagan (Ward Attendant Seto), Jimmie Ray Weeks (Prison Guard), Jack O'Connell (Corn Dog Stand Boss), Chas Mastin (Lyle Russel), Ajay Naidu (Mailman), Sean Gullette (Arnold the Shrink), Samia Shoaib (Nurse Mall), Abraham Abraham (King Neptune), Aliya Campbell (Alice), Te'ron A. O'Neal (Young Tyrone), Bryan Chattoo (Brody), Eddie De Harp (Brody's Henchman Victor), Scott Franklin (Voice of Jailer (voice)), Peter Cheyenne (Sal the Geep), Brian Costello (First AD), Abraham Aronofsky (Newspaper Man on Train), James Chinlund (Space Oddity) and others.

Hubert Selby Jr. (Screenplay), Darren Aronofsky (Screenplay), Palmer West (Producer), Eric Watson (Producer), Nick Wechsler (Executive Producer), Stefan Simchowitz (Executive Producer), Ann Ruark (Line Producer) more..., Beau Flynn (Executive Producer), Clint Mansell (Original Music Composer), Matthew Libatique (Director of Photography), Jay Rabinowitz (Editor), Ann Goulder (Casting), Anne McCarthy (Casting), Mary Vernieu (Casting), James Chinlund (Production Design), Judy Rhee (Art Direction), Ondine Karady (Set Decoration), Carolyn Grifel (Costume Design), Laura Jean Shannon (Costume Design), Lori Keith Douglas (Unit Production Manager), Douglas Wilkinson (Post Production Supervisor), Stephen Barden (Sound Designer), Brian Emrich (Sound Designer), Hubert Selby Jr. (Novel),