Dan Aykroyd (Louis Winthorpe III), Eddie Murphy (Billy Ray Valentine), Ralph Bellamy (Randolph Duke), Don Ameche (Mortimer Duke), Denholm Elliott (Coleman), Kristin Holby (Penelope Witherspoon), Paul Gleason (Clarence Beeks) more..., Jamie Lee Curtis (Ophelia), Alfred Drake (President of Exchange), Bo Diddley (Pawnbroker), Frank Oz (Corrupt Cop), Jim Belushi (Harvey), Al Franken (Baggage Handler #1), Tom Davis (Baggage Handler #2), Maurice Woods (Duke & Duke Employee), Richard D. Fisher, Jr. (Duke & Duke Employee), Jim Gallagher (Duke & Duke Employee), Anthony DiSabatino (Duke & Duke Employee), Bonnie Behrend (Duke & Duke Employee), Sunnie Merrill (Duke & Duke Employee), James Newell (Duke & Duke Employee), Mary St. John (Duke & Duke Employee), Bonnie Tremena (Duke & Duke Employee), David Schwartz (Duke & Duke Employee), Tom Degidon (Duke Domestic), William Magerman (Duke Domestic), Alan Dellay (Duke Domestic), Florence Anglin (Duke Domestic), Ray D'Amore (Duke Domestic), Bobra Suiter (Duke Domestic), Herb Peterson (Duke Domestic), Sue Dugan (Duke Domestic), Walt Gorney (Duke Domestic), B. Constance Barry (Duke Domestic), P. Jay Sidney (Heritage Club Doorman), Avon Long (Ezra), Tom Mardirosian (Officer Pantuzzi), Charles Brown (Officer Reynolds), Robert Curtis Brown (Todd), Nicholas Guest (Harry) and others.

Timothy Harris (Screenplay), Herschel Weingrod (Screenplay), George Folsey Jr. (Executive Producer), Aaron Russo (Producer), Irwin Russo (Producer), Sam Williams (Producer), Malcolm Campbell (Editor) more..., Bonnie Timmermann (Casting), Gene Rudolf (Production Design), George DeTitta Jr. (Set Decoration), George DeTitta Sr. (Set Decoration), Deborah Nadoolman (Costume Design), Robert Paynter (Director of Photography), Wolfgang Amadeus Mozart (Music), Elmer Bernstein (Original Music Composer), Linda Conaway-Parsloe (Assistant Art Director), Gary Jones (Assistant Costume Designer), Renee Bodner (Script Supervisor), Frank Bianco (Hairstylist), Jack Engel (Makeup Artist), Charles L. Campbell (Supervising Sound Editor), Frank Graziadei (Sound Recordist), James Sabat (Sound Mixer), Hank Muller (Assistant Camera), Samuel C. Crutcher (Sound Editor), Robert Knudson (Sound Re-Recording Mixer), Robert Glass (Sound Re-Recording Mixer), Larry Mann (Sound Editor), Don Digirolamo (Sound Re-Recording Mixer), Chuck Neely (Assistant Sound Editor), Bruce Richardson (Sound Editor), Jerry Stanford (Sound Editor), Larry Carow (Sound Editor), Andy Perillo (Special Effects),