Robert Downey Jr. (Sherlock Holmes), Jude Law (Dr. John Watson), Noomi Rapace (Madam Simza Heron), Jared Harris (Professor James Moriarty), Rachel McAdams (Irene Adler), Eddie Marsan (Inspector Lestrade), Kelly Reilly (Mary Morstan) more..., Stephen Fry (Mycroft Holmes), Paul Anderson (Colonel Sebastian Moran), Geraldine James (Mrs. Hudson), William Houston (Constable Clark), Wolf Kahler (Doctor Hoffmanstahl), Iain Mitchell (Auctioneer), Jack Laskey (Carruthers), Patricia Slater (Shush Club Maitre D'), Karima McAdams (Shush Club Maitre D'), Richard Cunningham (Businessman), Marcus Shakesheff (Hashisheen), Mark Sheals (Cock Fight Referee), George Taylor (University Student), Michael Webber (Vicar), Mike Grady (Train Conductor), Alexandre Carril (Twin), Victor Carril (Twin), Thorston Manderlay (Alfred Meinhard), Affif Ben Badra (Tamas), Daniel Naprous (Marko), Lancelot Weaver (Stefan), Vladimir Furdik (Andrzej), Alexander Devrient (Gypsy), Fatima Adoum (Gypsy), Stanley Kaye (Stanley), Thierry Neuvic (Claude Ravache), Martin Nelson (Commendatore), Mark Llewelyn-Evans (Don Giovanni), Anthony Inglis (Conductor), Ian Wilson-Pope (Leporello), Pamela Hay (Elvira), Laurence Dobiesz (Servant), Peter Stark (German Officer) and others.

Kieran Mulroney (Screenplay), Michele Mulroney (Screenplay), Hans Zimmer (Original Music Composer), Joel Silver (Producer), Jenny Beavan (Costume Design), Alison Harvey (Set Decoration), Katie Spencer (Set Decoration) more..., Sarah Greenwood (Production Design), Reg Poerscout-Edgerton (Casting), Philippe Rousselot (Director of Photography), Susan Downey (Producer), Dan Lin (Producer), Lionel Wigram (Producer), Bruce Berman (Executive Producer), Steve Clark-Hall (Executive Producer), Netty Chapman (Art Direction), Nick Gottschalk (Art Direction), Matthew Gray (Art Direction), Peter Burgis (Foley), Mark Holt (Special Effects Coordinator), Nina Armstrong (Stunts), Chas Jarrett (Visual Effects Supervisor), Sirio Quintavalle (Visual Effects Supervisor), Mark Henson (Stunt Coordinator), Markos Rounthwaite (Stunt Coordinator), James Herbert (Editor), James Foster (Art Direction), Arthur Conan Doyle (Characters), Niall Moroney (Supervising Art Director), Elizabeth West (Script Supervisor), Mark Mostyn (Unit Production Manager), Kevin Kaska (Orchestrator), Ethan Erwin (Co-Producer), Peter Eskelsen (Associate Producer), Lauren Meek (Co-Producer), Emma Zee (Post Production Supervisor), Remo Tozzi (Set Designer), Emma Callinan (Casting Assistant), Elodie Demey (Casting), Maxime Couteret (Location Manager) and others.