Robert Downey Jr. (Steve Lopez), Jamie Foxx (Nathaniel Ayers), Catherine Keener (Mary Weston), Tom Hollander (Graham Claydon), Nelsan Ellis (David Carter), Michael Bunin (Adam Crane), LisaGay Hamilton (Jennifer Ayers) more..., Rachael Harris (Leslie Bloom), Stephen Root (Curt Reynolds), Lorraine Toussaint (Flo Ayers), Jena Malone (Cheery Lab Tech), Octavia Spencer (Troubled Woman), Justin Martin (Young Nathaniel), Kokayi Ampah (Bernie Carpenter), Patrick Tatten (Paul Jr.), Susane Lee (Marisa), Marcos De Silvas (Mayor Villaigosa), Ilia Volok (Harry Barnoff), Mike Nowak (Julliard Conductor), David Jean Thomas (Angry Homeless Man), Lemon Andersen (Uncle Tommy), Kevin Michael Key (Homeless Transvestite), Moya Brady (Barely Dressed Woman), Orlando Ashley (LAMP Homeless Guy), Artel Great (Leon), J.J. Boone (Shouting Woman), Annie McKnight (LAMP Advocate), Bernadette Speakes (Homeless Lady), Anna Levin (Leeann), Steve Foster (Steve), Vivian George (Teresa), Kevin Cohen (KK), Courtney Andre (Courtney), Teri Hughes (Detroit), Linda Harris (Linda), Albert Olson (Bam Bam), Melissa Black (Melissa), Valarie Hudspeth (Mama Grouch), Darryl Black St. (Darryl), Kiana Parker (Kiana) and others.

Susannah Grant (Screenplay), Steve Lopez (Author), Patricia Whitcher (Executive Producer), Gary Foster (Producer), Russ Krasnoff (Producer), Paul Tothill (Editor), Francine Maisler (Casting) more..., Sarah Greenwood (Production Design), Greg Berry (Art Direction), Jacqueline Durran (Costume Design), Ve Neill (Makeup Department Head), Dominick Certo (Music Editor), Kerry Lyn McKissick (Script Supervisor), Robert Mazaraki (Production Coordinator), Dario Marianelli (Original Music Composer), Julie Smith (Set Decoration), François Duhamel (Still Photographer), Seamus McGarvey (Director of Photography), Gloria Pasqua Casny (Hair Department Head), Patricia Whitcher (Unit Production Manager), Adam Cole (Post Production Coordinator), C.C. Taylor (Stunts), Hannah Kozak (Stunts), Shirley Smrz (Stunts),