Sandra Bullock (Margaret Tate), Ryan Reynolds (Andrew Paxton), Malin Åkerman (Gertrude), Craig T. Nelson (Joe Paxton), Mary Steenburgen (Grace Paxton), Betty White (Grandma Annie), Denis O'Hare (Mr. Gilbertson) more..., Oscar Nunez (Ramone), Aasif Mandvi (Bob Spaulding), Michael Nouri (Chairman Bergen), Gregg Edelman (Lead Counsel Malloy), Michael Mosley (Chuck), Dale Place (Jim McKittrick), Alicia Hunt (Coffee Barista), Alexis Garcia (Immigration Clerk), Kortney Adams (Colden Books Receptionist), Chris Whitney (Medivac Pilot), Jerrell Lee Wesley (Jordan), Phyllis Kay (Mrs. McKittrick), Kate Lacey (Party Guest), Gene Fleming (Store Owner), Mary Linda Rapelye (Executive Secretary), Anne Fletcher (Jill), B. Johnson (Guy in Office), John Franchi (Taxicab Driver (uncredited)), Keith Fluker (Businessman (uncredited)), Dan Griffin (Businessman / Pedestrian on Sidewalk (uncredited)), London Hall (Wedding and Reception Guest (uncredited)), Dan Marshall (Lawyer at Publishing Company (uncredited)), Ron Murphy (Wedding Guest (uncredited)), Niecy Nash (Stewardess (uncredited)), Thomas Olson (Party Guest (uncredited)), Donna Glee Reim (Reception Guest (uncredited)), Rich Skinner (New York Cab Driver (uncredited)), Ylian Alfaro Snyder (Immigrant at INS Office (uncredited)), Uzimann (Pedestrian (uncredited)), Larry Vigus (Party Guest (uncredited))

Pete Chiarelli (Writer), Catherine Marie Thomas (Costume Design), David Hoberman (Producer), Todd Lieberman (Producer), Buck Damon (Music Supervisor), Melissa Muik (Music Editor), Zachary Woodlee (Associate Choreographer) more..., Aaron Zigman (Original Music Composer), Susanna David (Script Supervisor), Priscilla Nedd-Friendly (Editor), Oliver Stapleton (Director of Photography), Nelson Coates (Production Design), Denise Pizzini (Set Decoration), Ann Masterson (Makeup Department Head), Roberto Orci (Executive Producer), Alex Kurtzman (Executive Producer), Sandra Bullock (Executive Producer), Mary McLaglen (Executive Producer), Mary McLaglen (Unit Production Manager), Mike Massa (Stunt Coordinator), Scott Meehan (Art Direction), Jodi Baldwin (Costume Supervisor), Morgan Gjovik (Assistant Editor), Mateo Laboriel (Music Programmer), Zoë Bell (Stunt Double), Amanda Mackey (Casting), Cathy Sandrich Gelfond (Casting), Christopher Assells (Sound Effects Editor), Tricia Heine (Makeup Artist), Rich Sickler (First Assistant Director), Christian P. Minkler (Sound Re-Recording Mixer), Gina B. Cranham (Set Designer), Jon Taylor (Sound Re-Recording Mixer), Karen Baker Landers (Supervising Sound Editor), Peter Staubli (Sound Effects Editor), Dan Hegeman (Sound Effects Editor), Janine Rath (Hairstylist), Mark Vanselow (Stunt Double), Elizabeth Cecchini (Hairstylist), Brian Drewes (Visual Effects Producer) and others.