Nicolas Cage (Benjamin Franklin Gates), Diane Kruger (Abigail Chase), Justin Bartha (Riley Poole), Ed Harris (Mitch Wilkinson), Jon Voight (Patrick Gates), Helen Mirren (Emily Appleton), Harvey Keitel (Peter Sadusky) more..., Bruce Greenwood (USA President), Ty Burrell (Connor), Michael Maize (Daniel), Timothy V. Murphy (Seth), Alicia Coppola (FBI Agent Spellman), Armando Riesco (FBI Agent Hendricks), Albert Hall (Nichols), Joel Gretsch (Thomas Gates), Christian Camargo (John Wilkes Booth), Brent Briscoe (Michael O'Laughlen), William Brent (Charles Gates), Michael Manuel (Agent Craig), Brad Rowe (Agent Hopper), Zachary Gordon (Lincoln Conspiracy Kid), Peter Woodward (Palace Guard Haggis), Oliver Muirhead (Control Room Guard), Larry Cedar (Control Room Guard), Troy Winbush (Agent Hammer), Billy Devlin (Agent Sledge), William R. Johnson (Agent Stander), Richard Cutting (Agent Tyme), Alicia Leigh Willis (Lady Customer), Rachel Cora Wood (Girl Customer), Lisa Marie Sheldon (Jacqueline), Natalie Dreyfuss (Angry College Girl), Michael Stone Forrest (Press Secretary), David E. Goodman (Deputy Press Secretary), Susan Lynskey (Asst. Press Secretary), Patricia DiZebba (Press Secretary's Secretary), Grant Thompson (Costa Mesa Quarterback), Frank Herzog (Frank), Maryellen Aviano (Senator's Wife), Jon Abel (Senator) and others.

Jon Turteltaub (Producer), Jerry Bruckheimer (Producer), Chad Oman (Executive Producer), Barry H. Waldman (Executive Producer), Oren Aviv (Executive Producer), Charles Segars (Executive Producer), Cormac Wibberley (Screenplay) more..., Marianne Wibberley (Screenplay), John Schwartzman (Director of Photography), Dominic Watkins (Production Design), Judianna Makovsky (Costume Design), William Goldenberg (Editor), David Rennie (Editor), Amir Mokri (Director of Photography), Angie Jones (Animation), Randall D. Wilkins (Set Designer), Ted Elliott (Story), Terry Rossio (Story), Ronna Kress (Casting), Mike Stenson (Executive Producer), Pat Sandston (Associate Producer), Christopher Boyes (Sound Re-Recording Mixer), Bob Badami (Music Supervisor), John Frazier (Special Effects Coordinator), Doc Kane (ADR Mixer), Julian Ashby (Art Direction), Barry H. Waldman (Unit Production Manager), Drew Boughton (Supervising Art Director), Robin Beauchesne (Makeup Artist), Ilona Herman (Makeup & Hair), Ian Fox (Camera Operator), Geoffrey Hansen (First Assistant Director), Odin Benitez (Sound Effects Editor), Gregory Poirier (Story), Fainche MacCarthy (Set Decoration), Gary Wright (Sound Effects Editor), Kathe Swanson (Key Hair Stylist), Todd Toon (Sound Effects Editor), Kimberly Harris (Supervising ADR Editor), Eddie Yansick (Stunt Double) and others.