Jacob Tremblay (Auggie Pullman), Owen Wilson (Nate Pullman), Julia Roberts (Isabel Pullman), Izabela Vidovic (Via Pullman), Danielle Rose Russell (Miranda Navas), Mandy Patinkin (Mr. Tushman), Daveed Diggs (Mr. Browne) more..., Noah Jupe (Jack Will), Bryce Gheisar (Julian Albans), Millie Davis (Summer Dawson), Elle McKinnon (Charlotte Cody), Ali Liebert (Ms. Petosa), Nadji Jeter (Justin Hollander), Ty Consiglio (Amos Conti), Kyle Breitkopf (Miles Noury), James A Hughes (Henry Joplin), Nicole Oliver (Mrs. Will), Rachel Hayward (Mrs. Navas), Crystal Lowe (Melissa Albans), Steve Bacic (Julian Albans, Sr.), Ben Ratner (Mr. Davenport), Sônia Braga (Grandma), Izzy Lieberman (Reid Kingsley), Hannah Hoberman (Rebecca), Erika McKitrick (Ella), Lucia Thain (Savanna Wittenberg), Emily Delahunty (Ximena Chin), Sasha Neuhaus (Maya Markowitz), William Dickinson (Eddie Johnson), Armen Bagdasarov (Danny), Emma Tremblay (Michelle), Lidya Jewett (Lina Annan), Kaelyn Breitkopf (Angela), Emily Giannozio (Rebecca Gibbs), Haley Goldin (Mrs. Gibbs), Cameron Roberts (James), Grayson Maxwell Gurnsey (Wally), Maccie Margaret Chbosky (Young Olivia), Gidget (Daisy), Victoria Cruz (Science Fair Judge) and others.

David Hoberman (Producer), Todd Lieberman (Producer), Mark Livolsi (Editor), Steven Conrad (Screenplay), R.J. Palacio (Novel), Don Burgess (Director of Photography), Deborah Aquila (Casting) more..., Kara Eide (Casting), Tricia Wood (Casting), Kris Woznesensky (Casting), Kalina Ivanov (Production Design), Kendelle Elliott (Art Direction), Shannon Gottlieb (Set Decoration), Monique Prudhomme (Costume Design), Gina MacKay (Art Department Coordinator), Craig Henderson (Construction Coordinator), Dean Eilertson (Property Master), Keilah Boyle (Continuity), Susan Lambie (Script Supervisor), Stephanie Moore (Script Coordinator), Steve Woodley (Animal Coordinator), Alison Fraser (Assistant Costume Designer), Luisa Dalmagro (Costume Coordinator), Kayla Straub (Set Costumer), Jessica Aquila Cymerman (Casting Assistant), Katherine McArdle (Casting Assistant), Peter Wilke (Steadicam Operator), Dale Robinette (Still Photographer), John Dekker (Gaffer), Darin Wong (Dolly Grip), Julian Chapdelaine (Dolly Grip), Reid Cohoon (Key Grip), John Stewart (Visual Effects Supervisor), Michael Leder (Boom Operator), Kevin Zimmerman (Sound Editor), Perry Robertson (Supervising Sound Editor), Scott Sanders (Supervising Sound Editor), Robert A. Pandini (Hair Department Head), Aimee Macabeo (Hair Supervisor), Ailsa Macmillan (Key Hair Stylist) and others.