Hilary Swank (Claire Morgan), Robert De Niro (Stan Harris), Michelle Pfeiffer (Ingrid Withers), Josh Duhamel (Sam), Sarah Jessica Parker (Kim Doyle), Zac Efron (Paul), Lea Michele (Elise) more..., Ashton Kutcher (Randy), Halle Berry (Nurse Aimee), Jon Bon Jovi (Daniel Jensen), Katherine Heigl (Laura Carrington), Seth Meyers (Griffin Byrne), Jessica Biel (Tess Byrne), Til Schweiger (James Schwab), Carla Gugino (Spiritual Dr. Morriset), Cary Elwes (Stan's Doctor), Sofía Vergara (Ava), Hector Elizondo (Kominsky), Abigail Breslin (Hailey Doyle), Ludacris (Brendan), Sarah Paulson (Grace Schwab), Alyssa Milano (Nurse Mindy), Jake T. Austin (Seth), Katherine McNamara (Lily Bowman), Nat Wolff (Walter), Yeardley Smith (Maude), Ryan Seacrest (Himself), Michael Bloomberg (Himself), Fiona Choi (Balinese Woman - Resolution Tour), Jim Belushi (Building Super), Mara Davi (Mika), Cassidy Reiff (Piper), Russell Peters (Chef Sunil), Serena Poon (Chef Ming), Common (Soldier), Jackie Seiden (Bride Trish), Joey McIntyre (Groom Rory), Beth Kennedy (Piper's Mom), Larry Miller (Harley (segment "Ahern Party")), Christine Lakin (Waitress Alyssa) and others.

Katherine Fugate (Writer), Kevin Kaska (Orchestrator), Michael Tronick (Editor), Charles Minsky (Cinematography), Mark Friedberg (Production Design), Leslie E. Rollins (Set Decoration), Gary Jones (Costume Design) more..., Kim Jennings (Art Direction), Garry Marshall (Producer), John Debney (Music), Diana Pokorny (Executive Producer), Toby Emmerich (Executive Producer), Mike Karz (Producer), Wayne Allan Rice (Producer), Josie Rosen (Executive Producer), Michael Disco (Executive Producer), Samuel J. Brown (Executive Producer),