Hilary Swank (Claire Morgan), Michelle Pfeiffer (Ingrid), Zac Efron (Paul), Robert De Niro (Stan Harris), Halle Berry (Nurse Aimee), Jessica Biel (Tess Byrne), Seth Meyers (Griffin Byrne) more..., Til Schweiger (James Schwab), Katherine Heigl (Laura), Jon Bon Jovi (Jensen), Sofía Vergara (Ava), Ashton Kutcher (Randy), Lea Michele (Elise), Sarah Jessica Parker (Kim), Abigail Breslin (Hailey), Josh Duhamel (Sam), Ludacris (Brendan), Héctor Elizondo (Kominsky), Carla Gugino (Spiritual Dr. Morriset), Cary Elwes (Stan's Doctor), Alyssa Milano (Nurse Mindy), Sarah Paulson (Grace Schwab), Russell Peters (Chef Sunil), Jake T. Austin (Seth), Larry Miller (Harley), Charlotte Marshall-Fricker (Caring Teenage Girl), Fiona Choi (Balinese Woman), Mary Marguerite Keane (Pet Adoption Clerk), Michael Mandell (Murray), Patrick Reale (Times Square Cop), Common (Soldier), Barbara Marshall (Head Nurse Helen), Amber Bela Muse (Nurse Risa), Peter Allen Vogt (Male Nurse), Ross Ryman (Pedicab Driver), Kal Parekh (Male Obstetrician), Serena Poon (Chef Ming), Sarge (Monty), Jim Belushi (Building Super), Lillian Lifflander (Mrs. Lifflander) and others.

Katherine Fugate (Writer), Kevin Kaska (Orchestrator), Michael Tronick (Editor), Mark Friedberg (Production Design), Leslie E. Rollins (Set Decoration), Gary Jones (Costume Design), Kim Jennings (Art Direction) more..., Garry Marshall (Producer), Diana Pokorny (Executive Producer), Toby Emmerich (Executive Producer), Mike Karz (Producer), Wayne Allan Rice (Producer), Josie Rosen (Executive Producer), Michael Disco (Executive Producer), Samuel J. Brown (Executive Producer), G.A. Aguilar (Stunt Coordinator), Aja Frary (Stunt Double), Shawnna Thibodeau (Stunt Double), Declan Mulvey (Stunt Double), Blaise Corrigan (Stunt Coordinator), Charles Minsky (Director of Photography), John Debney (Original Music Composer), James McMillan (Key Grip), Shannon Triplett (VFX Production Coordinator),