Nicolas Cage (Seth), Meg Ryan (Maggie), Dennis Franz (Messinger), Andre Braugher (Cassiel), Colm Feore (Jordan), Robin Bartlett (Anne), Joanna Merlin (Teresa) more..., Sarah Dampf (Susan), Rhonda Dotson (Susan's Mother), Nigel Gibbs (Doctor), John Putch (Man in Car), Lauri Johnson (Woman in Car), Christian Aubert (Foreign Visitor in Car), Jay Patterson (Air Traffic Controller), Shishir Kurup (Anesthesiologist), Brian Markinson (Surgical Fellow), Hector Velasquez (Scrub Nurse), Marlene Kanter (Circulating Nurse #1), Bernard White (Circulating Nurse #2), Dan Desmond (Mr. Balford), Deirdre O'Connell (Mrs. Balford), Kim Murphy (Balford's Daughter), Chad Lindberg (Balford's Son), Alexander Folk (Convenience Store Clerk), Rainbow Borden (Holdup Man), Harper Roisman (Old Man in Library), Sid Hillman (Librarian), Wanda-Lee Evans (Nurse in Messinger's Room), Wanda Christine (Station Nurse), E.J. Callahan (Waiter at Johnnie's), Tudi Roche (Messinger's Daughter), David Moreland (Husband Frank), Kristina Malota (Hannah), William Stanford Davis (Construction Foreman), Mik Scriba (Construction Worker), Nick Offerman (Construction Worker), Kieu Chinh (Asian Woman), Geoffrey Thorne (Big Orderly), Peter Spellos (Mack Truck Driver), Jim Kline (Store Clerk) and others.

Dana Stevens (Screenplay), Charles Roven (Producer), Dawn Steel (Producer), Gabriel Yared (Original Music Composer), John Seale (Director of Photography), Lynzee Klingman (Editor), Mark Mangini (Supervising Sound Editor) more..., Ronna Kress (Casting Associate), Robert Cavallo (Executive Producer), Arnon Milchan (Executive Producer), Vince Deadrick Jr. (Stunts), Lilly Kilvert (Production Design), John Warnke (Art Direction), Gretchen Rau (Set Decoration), Jess Gonchor (Construction Foreman), Gabriel Yared (Orchestrator), David Rubin (Casting), Ellen Heuer (Foley Artist), Marilyn Graf (Foley Mixer), Rick Seaman (Stunts), Jeff Levine (Associate Producer), Alan Glazer (Associate Producer), Ezra Dweck (Foley Editor), Charles Newirth (Executive Producer), Keith Campbell (Stunts), Shay Cunliffe (Costume Design), Adam Boome (Associate Editor), Dianne Wager (Assistant Art Director), Joe Bucaro III (Stunts), Allegra Clegg (Unit Production Manager), Kelley Smith-Wait (Co-Producer), Thomas Rosales Jr. (Stunts), Patrick Cassidy (Leadman), Michele Panelli-Venetis (First Assistant Director), Matt Rebenkoff (Second Assistant Director), Morris Flam (Chief Lighting Technician), Jason Rodriguez (Stunts), Thomas R. Burman (Makeup Effects Designer), Eric Chambers (Stunts), Harry Rabinowitz (Conductor) and others.