Kenneth Branagh (Hercule Poirot), Tom Bateman (Bouc), Michelle Pfeiffer (Caroline Hubbard), Johnny Depp (Edward Ratchett), Josh Gad (Hector MacQueen), Willem Dafoe (Gerhard Hardman), Judi Dench (Princess Dragomiroff) more..., Derek Jacobi (Edward Henry Masterman), Leslie Odom Jr. (Dr. Arbuthnot), Daisy Ridley (Miss Mary Debenham), Penélope Cruz (Pilar Estravados), Olivia Colman (Hildegarde Schmidt), Lucy Boynton (Countess Elena Andrenyi), Marwan Kenzari (Pierre Michel), Manuel Garcia-Rulfo (Biniamino Marquez), Sergei Polunin (Count Rudolph Andrenyi), Paapa Essiedu (Young Policeman), Yassine Zeroual (Young Boy), Asan N'Jie (Hotel Waiter), Michael Rouse (British Police Chief Inspector), Elliot Levey (Rabbi), David Annen (Priest), Joseph Long (Imam), Andy Apollo (Armed Policeman), Hadley Fraser (British Military Escort), Ziad Abaza (Arab Shipmate), Nari Blair-Mangat (Waiter), Luke Brady (Waiter), Miltos Yerolemou (Old Turk Baker), Kathryn Wilder (Prostitute), Gerard Horan (Aynesworth), Richard Clifford (Maître d'), Sid Sagar (Sleeping Car Attendant), Adam Garcia (Italian Fan), Harry Lister Smith (Stockman), Darryl Clark (Salon Barman), Anoushka Lucas (Pianist), Matthew Hawksley (Waiter), Crispin Letts (Head Waiter), Yasmin Harrison (Dining Car Sous Chef) and others.

Michael Green (Screenplay), Agatha Christie (Novel), Patrick Doyle (Original Music Composer), Haris Zambarloukos (Director of Photography), Mick Audsley (Editor), Lucy Bevan (Casting), Jim Clay (Production Design) more..., Winston Azzopardi (Line Producer), Kenneth Branagh (Producer), Mark Gordon (Producer), Judy Hofflund (Producer), Simon Kinberg (Producer), William Moseley (Associate Producer), James Prichard (Executive Producer), Michael Schaefer (Producer), Ridley Scott (Producer), Aditya Sood (Producer), Hilary Strong (Executive Producer), Andrew Ackland-Snow (Art Direction), Will Coubrough (Art Direction), Jordana Finkel (Art Direction), Phil Harvey (Art Direction), Dominic Masters (Supervising Art Director), Alexandra Byrne (Costume Design), Charlo Dalli (Art Direction), Rebecca Alleway (Set Decoration), Emily Brockmann (Casting Associate), Sam Dormer (Armorer), Janet Kellock (Script Supervisor), Nicoletta Mani (Script Supervisor), Sylvia Parker (Script Supervisor), Marc Wolff (Aerial Coordinator), Lucia Foster Found (Aerial Coordinator), Robin Morrison (Music Editor), Graham Sutton (Music Editor), Cecile Tournesac (Music Editor), Richard Sale (Assistant Costume Designer), Kate Chadderton (Costume Coordinator), Martina Zammit Maempel (Costume Coordinator), Dan Grace (Costume Supervisor) and others.