Tom Holland (Peter Parker / Spider-Man), Michael Keaton (Adrian Toomes / Vulture), Robert Downey Jr. (Tony Stark / Iron Man), Marisa Tomei (May Parker), Jon Favreau (Harold 'Happy' Hogan), Gwyneth Paltrow (Virginia 'Pepper' Potts), Zendaya (Michelle 'MJ' Jones) more..., Donald Glover (Aaron Davis), Jacob Batalon (Ned), Laura Harrier (Liz), Tony Revolori (Eugene 'Flash' Thompson), Bokeem Woodbine (Herman Schultz / Shocker), Tyne Daly (Anne Marie Hoag), Abraham Attah (Abraham), Hannibal Buress (Coach Wilson), Kenneth Choi (Principal Morita), Selenis Leyva (Ms. Warren), Angourie Rice (Betty Brant), Martin Starr (Mr. Harrington), Garcelle Beauvais (Doris Toomes), Michael Chernus (Phineas Mason / Tinkerer), Michael Mando (Mac Gargan), Logan Marshall-Green (Jackson Brice / Shocker), Jennifer Connelly (Karen (voice)), Gary Weeks (Agent Foster), Christopher Berry (Randy), Jorge Lendeborg Jr. (Jason Ionello), Tunde Adebimpe (Mr. Cobbwell), Tiffany Espensen (Cindy), Isabella Amara (Sally), Michael Barbieri (Charles), Josie Totah (Seymour), Hemky Madera (Mr. Delmar), Zach Cherry (Street Vendor), Kirk R. Thatcher (Punk on Street), Yu Lew (Car Jacker), Sondra James (Yelling Woman), Bob Adrian (Yelling Man), Gary Richardson (Day Sleeper), Stan Lee (Gary) and others.

Kevin Feige (Producer), Amy Pascal (Producer), Steve Ditko (Characters), Stan Lee (Characters), Stan Lee (Executive Producer), Sarah Halley Finn (Casting), Eric Hauserman Carroll (Co-Producer) more..., Oliver Scholl (Production Design), Louise Frogley (Costume Design), Lauren Abiouness (Art Direction), Beat Frutiger (Art Direction), Gene Serdena (Set Decoration), Debbie Berman (Editor), Kellie Robinson (Hairstylist), Leeann Stonebreaker (Unit Production Manager), Nadia Paine (Unit Production Manager), Rachel Block (Assistant Art Director), Chris Diebold (Sound Effects Editor), Luis Galdames (Sound Effects Editor), Joe Lemola (Sound Effects Editor), Bob Kellough (Sound Effects Editor), Felipe Borrero (Sound Mixer), Jonathan Goldstein (Screenstory), John Francis Daley (Screenstory), Dan Lebental (Editor), Audra Avery (Art Direction), Drew Monahan (Art Direction), Brad Ricker (Supervising Art Director), Lauri Gaffin (Set Decoration), Jeri Baker (Hair Department Head), Suzanna Boykin (Hairstylist), Michelle Diamantides (Hairstylist), Cynthia L. Chapman (Hair Department Head), Jillian Erickson (Makeup Department Head), Greg Funk (Key Makeup Artist), Jack Lazzaro (Makeup Artist), Suzy Mazzarese-Allison (Key Hair Stylist), Ashley McGuire (Makeup Artist), Joseph Negrete (Hairstylist), Seidah Nichols (Makeup Artist) and others.