Oakes Fegley (Ben Wilson), Millicent Simmonds (Rose Kincaid), Julianne Moore (Lillian Mayhew), Michelle Williams (Elaine Wilson), Jaden Michael (Jamie), Cory Michael Smith (Walter Kincaid), Tom Noonan (Older Walter Kincaid) more..., Amy Hargreaves (Aunt Jenny), James Urbaniak (Dr. Kincaid), Hays Wellford (Greg Coons), Damian Young (Otto), Morgan Turner (Janet), Ekaterina Samsonov (Hanna), Anthony Natale (Dr. Gill, Teacher of the Deaf), Sawyer Nunes (Robby), Brian Berrebbi (Stage Manager), Michael Wren Gucciardo (Man Who Jumps in Car at Movies), Tom Waters (1970s Business Man), Patrick Murney (Workman), Connor Moeller (Museum Boy), Mackenzie Grace Castle (Museum Girl), Derek Chadwick (Liam (uncredited)), Raul Torres (Jamie's Father), Lauren Ridloff (Pearl, The Maid), Logan Taylor (Promenade Child / Museum Child (uncredited))

Edward Lachman (Director of Photography), Brian Selznick (Novel), Brian Selznick (Writer), Paul Molnar (Makeup Artist), Brian Bell (Executive Producer), Pamela Koffler (Producer), Frank Murray (Co-Producer) more..., John Sloss (Producer), Christine Vachon (Producer), Carter Burwell (Music), Affonso Gonçalves (Editor), Laura Rosenthal (Casting), Mark Friedberg (Production Design), Ryan Heck (Art Direction), Kim Jennings (Art Direction), Debra Schutt (Set Decoration), Sandy Powell (Costume Design), Monique Benoit (Makeup Artist), Jerry DeCarlo (Hair Department Head), Gary Martori (Hairstylist), Suzy Mazzarese-Allison (Hairstylist), Patricia Regan (Makeup Department Head), Tomasina Smith (Makeup Artist), Brian Bell (Unit Production Manager), Timothy Bird (First Assistant Director), Michael Auszura (Assistant Art Director), Stephen Barth (Scenic Artist), Eric Lewis Beauzay (Assistant Art Director), Katya Blumenberg (Assistant Art Director), Marc Connor (Scenic Artist), Nathaniel Davis (Set Dresser), Dan Decelle (Set Dresser), Eric Fehlberg (Conceptual Illustrator), Roman Greller (Set Dresser), Sandy Hamilton (Property Master), Candis Heiland (Set Dresser), Erica Hohf (Assistant Art Director), Rumiko Ishii (Assistant Art Director), Christopher Kay (Scenic Artist), Tina Khayat (Set Decorating Coordinator) and others.