Oakes Fegley (Ben), Millicent Simmonds (Rose), Julianne Moore (Lillian Mayhew / Rose), Michelle Williams (Elaine), Cory Michael Smith (Walter), James Urbaniak (Dr. Kincaid, Rose's Father) more..., Damian Young (Otto, Museum Guard), Patrick Murney (Workman), Lauren Ridloff (Pearl, The Maid), Anthony Natale (Dr. Gill, Teacher of the Deaf), Carole Addabbo (Miss Conrad at the Museum), Howard Seago (Remy Rubin, Theater Director), Brian Berrebbi (Stage Manager), John P. McGinty (Valentin), Mark A. Keeton (Shopkeeper), Patrick Wiley (Window Dresser), Garrett Zuercher (Officer Engel), Jared Johnston (Officer Murtha), Murphy Guyer (Security Chief), Ekaterina Samsonov (Hannah), Sawyer Niehaus (Blessing), Lilianne Rojek (Florence), Michael W. Gaines (Butler), Jaden Michael (Jamie), Tom Noonan (Walter), Morgan Turner (Janet), Amy Hargreaves (Aunt Jenny), Sawyer Nunes (Robbie), Raul Torres (Jamie's Father), Mandela Bellamy (Woman on Bus), Jim Lavin (ER Doctor), Colleen Cosgrove (ER Nurse), Hays Wellford (Greg Coons at the Bus Stop), Asa Liebmann (Thief), John Boyd (Danny), Oladamolami Adisa (Signing Hands), Mylo Barrett (Signing Hands), Robinho Cruz (Signing Hands), Vanessa DeLeon (Signing Hands), Jordana Lurman (Signing Hands) and others.

Edward Lachman (Director of Photography), Brian Selznick (Novel), Brian Selznick (Writer), Paul Molnar (Makeup Artist), Brian Bell (Executive Producer), Pamela Koffler (Producer), Frank Murray (Co-Producer) more..., John Sloss (Producer), Christine Vachon (Producer), Affonso Gonçalves (Editor), Laura Rosenthal (Casting), Mark Friedberg (Production Design), Ryan Heck (Art Direction), Kim Jennings (Art Direction), Debra Schutt (Set Decoration), Sandy Powell (Costume Design), Monique Benoit (Makeup Artist), Jerry DeCarlo (Hair Department Head), Gary Martori (Hairstylist), Suzy Mazzarese-Allison (Hairstylist), Patricia Regan (Makeup Department Head), Tomasina Smith (Makeup Artist), Brian Bell (Unit Production Manager), Timothy Bird (First Assistant Director), Michael Auszura (Assistant Art Director), Stephen Barth (Scenic Artist), Eric Lewis Beauzay (Assistant Art Director), Katya Blumenberg (Assistant Art Director), Marc Connor (Scenic Artist), Nathaniel Davis (Set Dresser), Dan Decelle (Set Dresser), Eric Fehlberg (Conceptual Illustrator), Roman Greller (Set Dresser), Sandy Hamilton (Property Master), Candis Heiland (Set Dresser), Erica Hohf (Assistant Art Director), Rumiko Ishii (Assistant Art Director), Christopher Kay (Scenic Artist), Tina Khayat (Set Decorating Coordinator), Jim Lillis (Set Dresser) and others.