Eddie Redmayne (Stephen Hawking), Felicity Jones (Jane Hawking), Charlie Cox (Jonathan Hellyer Jones), Emily Watson (Beryl Wilde), Simon McBurney (Frank Hawking), David Thewlis (Dennis Sciama), Maxine Peake (Elaine Mason) more..., Harry Lloyd (Brian), Tom Prior (Robert Hawking (Age 17)), Sophie Perry (Lucy Hawking (Age 14)), Finlay Wright-Stephens (Timothy Hawking (Age 8)), Alice Orr-Ewing (Diana King), Thomas Morrison (Carter), Michael Marcus (Ellis), Gruffudd Glyn (Rees), Paul Longley (Barman - Rowing Club), Guy Oliver-Watts (George Wilde), Lucy Chappell (Mary Hawking), Charlotte Hope (Philippa Hawking), Abigail Cruttenden (Isobel Hawking), Nicholas Gerard-Martin (Physicist #1), Brett Brown (Physicist #2), Anthony Skrimshire (Physicist #3), Christian McKay (Roger Penrose), Adam Godley (Senior Doctor - Cambridge Hospital), Nicola Sloane (Bedder), Lottie Hamilton (Robert Hawking (New Born)), Enzo Cilenti (Kip Thorne), Rufus Taylor (Robert Hawking (Age 2)), Delilah Sexton (Lucy Hawking (New Born)), Eileen Davies (Eileen Bond), Simon Chandler (John Taylor), Georg Nikoloff (Khalatnikov), Oliver Payne (Robert Hawking (Age 8)), Raffiella Chapman (Lucy Hawking (Age 6)), Sam Houston (Timothy Hawking (Baby)), Victoria Emslie (Sarah (Geneva Student)), Frank Lebœuf (Swiss Doctor), Will Barton (Technician), Lucy Challenger (Female Fan) and others.

Benoît Delhomme (Director of Photography), Eric Fellner (Producer), Lisa Bruce (Producer), Anthony McCarten (Producer), Jinx Godfrey (Editor), John Paul Kelly (Production Design), Clare Nia Richards (Set Decoration) more..., Stephen Noble (Costume Design), Tim Bevan (Producer), Nina Gold (Casting), Agnes Legere (Hairstylist), Kira Kemble (Assistant Art Director), Adam Scrivener (Sound Re-Recording Mixer), Ian Tapp (Sound Re-Recording Mixer), Glenn Freemantle (Supervising Sound Editor), Glenn Marks (Stunt Coordinator), Pat Sweeney (Gaffer), Natasha Cousins (Costume Supervisor), Mark Keady (First Assistant Editor), Allan Jenkins (Music Editor), Sylvia Parker (Script Supervisor), Rebecca Pearson (Location Manager), David Campbell-Bell (Location Manager), Jill McCullough (Dialect Coach), Rachel Kennedy (Unit Publicist), Jane Hawking (Book), Danny Freemantle (Sound Designer), Gerry Vasbenter (Steadicam Operator), Lesley Smith (Key Makeup Artist), Liam McGill (Rigging Gaffer), Liam Daniel (Still Photographer), Paul Wrightson (ADR Editor), Sarah Bridge (Music Supervisor), Claire Freeman (Music Supervisor), John Warhurst (Music Editor), Anthony Weeden (Orchestrator), Jóhann Jóhannsson (Orchestrator), Anthony McCarten (Screenplay), Amelia Granger (Executive Producer), Liza Chasin (Executive Producer) and others.