Cate Blanchett (Bernadette), Billy Crudup (Elgie), Kristen Wiig (Audrey), Judy Greer (Dr. Kurtz), Laurence Fishburne (Paul Jellinek), Emma Nelson (Bee), Troian Bellisario (Becky) more..., James Urbaniak (Agent Marcus Strang), Megan Mullally (Judy Toll), Richard Robichaux (Floyd the Pharmacist), Kate Burton (Ellen Idelson), Steve Zahn (David Walker), David Paymer (Jay Ross), Zoë Chao (Soo-Lin), Patrick Sebes (Tom the Blackberry Guy), Lee Harrington (USC Student), Patrick Jordan (Game Show Host), Shaun Cameron Hall (Pablo), Kathryn Feeney (Tamara the Pharmacy Employee), Amy Rayko (Lisa Prospective Parent), Nancy McNulty (Lori Prospective Parent), Daina Griffith (Julie Prospective Parent), Kate Easton (Tammy Prospective Parent), Stephen Donnelly (Mr. Hayes), Thalia Torio (Kennedy), Mark Philip Stevenson (Architectural Expert), Cherie McClain (News Reporter), Maureen d'Armand (Crew Member Allegra), Jóhannes Haukur Jóhannesson (Captain J. Rouverol), Claudia Doumit (Iris), Katelyn Statton (Vivian), Jennifer Tober (Snappy Tourist Lady), Joe Coyle (Mike the State Senator), Richard Barlow (Stu Reardon (Microsoft Executive) (uncredited)), Tom Bonello (Pharmacy Patron (uncredited)), Brian 'Wolfman Black' Bowman (Parent (uncredited)), Gregory Bromfield (Caterer (uncredited)), Zachary Davis Brown (Kyle's Friend (uncredited)), Owen Buckenmaier (Kyle (uncredited)), Isaac J. Conner (Passenger (uncredited)) and others.

Nina Jacobson (Producer), Brad Simpson (Producer), Ginger Sledge (Producer), Vincent Palmo Jr. (Screenplay), Richard Linklater (Screenplay), Holly Gent (Screenplay), Sandra Adair (Editor) more..., Maria Semple (Novel), Megan Ellison (Executive Producer), Jillian Longnecker (Executive Producer), Maria Semple (Executive Producer), Graham Reynolds (Original Music Composer), Shane F. Kelly (Director of Photography), Vicky Boone (Casting Director), Bruce Curtis (Production Design), Gregory A. Weimerskirch (Art Direction), Beauchamp Fontaine (Set Decoration), Kari Perkins (Costume Design), Tom Hammond (Sound Re-Recording Mixer), Robert Grasmere (Visual Effects Supervisor), Justin Hennard (Sound Designer), Morag Ross (Makeup Artist), Raoul Bolognini (Visual Effects Producer), Rusty Ippolito (VFX Artist), Darylin Nagy (Makeup Department Head), Nathan Inglesby (Visual Effects), Nancy Heller (Visual Effects Producer), Patty Bell (Makeup Artist), Christopher Patrick (Makeup Artist), Talia K. Dillingham (Stunt Double), Shauna Galligan (Stunt Double), Shawnna Thibodeau (Stunt Double), Liz Kelley (Casting Associate), Brittany Hites (Assistant Art Director), Kara Rosella (Stunts), Alex Benevent (Stunts), Vincent Palmo Jr. (First Assistant Director), Susan Ransom-Coyle (Second Assistant Director), Jordan Weir (Second Second Assistant Director), Jennifer Bechak (Sculptor) and others.