Eddie Murphy (Prince Akeem / Clarence / Randy Watson / Saul), Arsenio Hall (Semmi / Extremely Ugly Girl / Morris / Reverend Brown), James Earl Jones (King Jaffe Joffer), John Amos (Cleo McDowell), Shari Headley (Lisa McDowell), Frankie Faison (Landlord), Louie Anderson (Maurice) more..., Eriq La Salle (Darryl Jenks), Allison Dean (Patrice McDowell), Madge Sinclair (Queen Aoleon), Paul Bates (Oha), Samuel L. Jackson (Hold-Up Man), Ralph Bellamy (Randolph Duke / Homeless Man #1 (uncredited)), Don Ameche (Mortimer Duke / Homeless Man #2 (uncredited)), Vanessa Bell Calloway (Imani Izzi), Calvin Lockhart (Colonel Izzi), Garcelle Beauvais (Rose Bearer #3), Cuba Gooding Jr. (Boy Getting Haircut), Birdie M. Hale (Elderly Passenger), Vondie Curtis-Hall (Basketball Game Vendor), Clyde Jones (Soul Glo Man), Jim Abrahams (Face on Cutting Room Floor), Feather (Rose Bearer), Stephanie Simon (Rose Bearer), Victoria Dillard (Bather / Dancer), Felicia Taylor (Bather), Midori (Bather), Sheila Johnson (Lady-in-Waiting), Jake Steinfeld (Cab Driver), Clint Smith (Sweets), Uncle Ray Murphy (Stu), Ruben Santiago-Hudson (Street Hustler), Paulette Banoza (Soul Glo Woman), Patricia Matthews (Devil Woman), Mary Bond Davis (Big Stank Woman), Carla Earle (Tough Girl), Karen Owens (Ex-Siamese Twin / Dancer), Sharon Owens (Ex-Siamese Twin / Dancer), Lisa Gumora (Kinky Girl), June Boykins (Strange Woman) and others.

David Sheffield (Screenplay), Barry W. Blaustein (Screenplay), Leslie Belzberg (Executive Producer), George Folsey Jr. (Producer), Mark Lipsky (Executive Producer), Robert D. Wachs (Producer), Nile Rodgers (Original Music Composer) more..., Sol Negrin (Director of Photography), Woody Omens (Director of Photography), Malcolm Campbell (Editor), George Folsey Jr. (Editor), Eddie Murphy (Story), David Sosna (Associate Producer), Jackie Burch (Casting), Richard Macdonald (Production Design), Richard B. Lewis (Art Direction), Christopher Nowak (Art Direction), Cheryal Kearney (Set Decoration), Dan von Blomberg (Set Decoration), Deborah Nadoolman (Costume Design), Carole Lee Cole (Assistant Art Director), Jerry Fitzpatrick (Construction Coordinator), William Apperson (Construction Foreman), Philip C. Hurst (Greensman), R. Gilbert Clayton (Set Designer), Ken Fisher (First Assistant Camera), Bruce Atwater (Grip), Bruce McBroom (Still Photographer), Kelly Kimball (Assistant Costume Designer), Francine Jamison-Tanchuck (Costume Supervisor), Rolf John Keppler (Makeup Artist), Gerald DeTitta (Set Dressing Artist), Marc Fambro (Carpenter), Paula Abdul (Choreographer), Eddie Jones (Craft Service), Patrick Hogan (Driver), Rick Baker (Makeup Effects), Gregg H. Bilson (Property Master), Edward Garzero (Scenic Artist), Greg Knapp (Set Medic) and others.