Tom Hanks (Joe Fox), Meg Ryan (Kathleen Kelly), Katie Sagona (Young Kathleen Kelly), Greg Kinnear (Frank Navasky), Parker Posey (Patricia Eden), Jean Stapleton (Birdie Conrad), Steve Zahn (George Pappas) more..., Heather Burns (Christina Plutzker), Dabney Coleman (Nelson Fox), Hallee Hirsh (Annabelle Fox), Dave Chappelle (Kevin Jackson), John Randolph (Schulyer Fox), Cara Seymour (Gillian Quinn), Deborah Rush (Veronica Cash), Chris Messina (Fox Salesperson), Jeffrey Scaperrotta (Matt Fox), Katie Finneran (Maureen, the Nanny), Michael Badalucco (Charlie), Veanne Cox (Miranda Margulies), Bruce Jay Friedman (Vince Mancini), Sara Ramirez (Rose, Zabars Cashier), Howard Spiegel (Henry, Zabars Shopper), Jane Adams (Sydney Anne)

Miklós László (Theatre Play), Nora Ephron (Screenplay), Delia Ephron (Screenplay), G. Mac Brown (Executive Producer), Julie Durk (Executive Producer), Delia Ephron (Executive Producer), Nora Ephron (Producer) more..., Lauren Shuler Donner (Producer), George Fenton (Original Music Composer), John Lindley (Director of Photography), Richard Marks (Editor), Dan Davis (Production Design), Albert Wolsky (Costume Design), Susan Bode (Set Decoration), Ellen Christiansen (Set Decoration), Francine Maisler (Casting), Dianne Dreyer (Script Supervisor), Brian Hamill (Still Photographer), Ron Bochar (Sound Re-Recording Mixer), Ron Bochar (Supervising Sound Editor), Lee Dichter (Sound Re-Recording Mixer), Lewis Goldstein (Sound Effects Editor), Donald J. Lee Jr. (Unit Production Manager), Nicholas Meyers (Music Supervisor), John Scott Cook (First Assistant Editor), Beth Kuhn (Art Direction), Ray Kluga (Art Direction), Chris Newman (Production Sound Mixer), Ray Fisher (Greensman), Nicholas Renbeck (Dialogue Editor), Magdaline Volaitis (Dialogue Editor), Kam Chan (Foley Editor), Frank Kern (Foley Editor), James Mazzola (Property Master), Don Kozma (Makeup Artist), John Quaglia (Hairstylist),