Tom Hanks (Joe Fox), Meg Ryan (Kathleen Kelly), Greg Kinnear (Frank Navasky), Parker Posey (Patricia Eden), Steve Zahn (George Pappas), Dave Chappelle (Kevin Jackson), Dabney Coleman (Nelson Fox) more..., Jean Stapleton (Birdie Conrad), Heather Burns (Christina Plutzker), John Randolph (Schulyer Fox), Hallee Hirsh (Annabelle Fox), Jeffrey Scaperrotta (Matt Fox), Cara Seymour (Gillian Quinn), Katie Finneran (Maureen, the Nanny), Michael Badalucco (Charlie), Deborah Rush (Veronica Cash), Veanne Cox (Miranda Margulies), Bruce Jay Friedman (Vince Mancini), Sara Ramirez (Rose, Zabars Cashier), Howard Spiegel (Henry, Zabars Shopper), Diane Sokolow (Zabars Shopper), Julie Kass (Zabars Shopper), Reiko Aylesworth (Thanksgiving Guest), Katie Sagona (Young Kathleen Kelly), Kathryn Meisle (Cecilia Kelly), Nina Zoie Lam (T.V. Reporter), Maggie Murphy (Theater Patron), Michelle Blakely (Shopper), Meredith White (Shopper), Dianne Dreyer (Shopper), Julie Galdieri (Shopper), Leila Nichols (Shopper), Mary A. Kelly (Fox Books Shopper), Chris Messina (Fox Salesperson), Ronobir Lahiri (Man at Cafe Lalo), André Sogliuzzo (Waiter at Lalo), Peter A. Mian (Capeman), Richard Cohen (Starbucks Customer), Enzo Angileri (Starbucks Customer), Nick Brown (Juggler) and others.

Miklós László (Theatre Play), Nora Ephron (Screenplay), Delia Ephron (Screenplay), G. Mac Brown (Executive Producer), Julie Durk (Executive Producer), Delia Ephron (Executive Producer), Nora Ephron (Producer) more..., Lauren Shuler Donner (Producer), George Fenton (Original Music Composer), John Lindley (Director of Photography), Richard Marks (Editor), Dan Davis (Production Design), Albert Wolsky (Costume Design), Susan Bode Tyson (Set Decoration), Ellen Christiansen (Set Decoration), Francine Maisler (Casting), Dianne Dreyer (Script Supervisor), Brian Hamill (Still Photographer), Ron Bochar (Sound Re-Recording Mixer), Ron Bochar (Supervising Sound Editor), Lee Dichter (Sound Re-Recording Mixer), Lewis Goldstein (Sound Effects Editor), Donald J. Lee Jr. (Unit Production Manager), Nicholas Meyers (Music Supervisor), John Scott Cook (First Assistant Editor), Beth Kuhn (Art Direction), Ray Kluga (Art Direction), Chris Newman (Production Sound Mixer), Ray Fisher (Greensman), Nicholas Renbeck (Dialogue Editor), Magdaline Volaitis (Dialogue Editor), Kam Chan (Foley Editor), Frank Kern (Foley Editor), James Mazzola (Property Master), Don Kozma (Makeup Artist), John Quaglia (Hairstylist), Donald J. Lee Jr. (Co-Producer), Dianne Dreyer (Associate Producer), Betsy Sokolow-Sherman (Unit Publicist), Jeremy Strong (Production Assistant) and others.