Jack Nicholson (Melvin Udall), Helen Hunt (Carol Connelly), Greg Kinnear (Simon Bishop), Cuba Gooding Jr. (Frank Sachs), Shirley Knight (Beverly Connelly), Jesse James (Spencer Connelly), Yeardley Smith (Jackie Simpson) more..., Lupe Ontiveros (Nora Manning), Skeet Ulrich (Vincent Lopiano), Harold Ramis (Dr. Bettes), Lawrence Kasdan (Dr. Green), Bibi Osterwald (Neighbor Woman), Ross Bleckner (Carl), Bernadette Balagtas (Caterer), Jaffe Cohen (Partygoer), Laurie Kilpatrick (Partygoer), Alice Vaughn (Partygoer), Brian Doyle-Murray (Handyman), Kristi Zea (Mother at Table), Annie Maginnis Tippe (Daughter at Table), Patricia Childress (Cafe 24 Waitress), Rebekah Johnson (Cafe 24 Waitress), Missi Pyle (Cafe 24 Waitress), Leslie Stefanson (Cafe 24 Waitress), Tara Subkoff (Cafe 24 Waitress), Shane Black (Cafe 24 Manager), Peter Jacobson (Man at Table), Lisa Edelstein (Woman at Table), Stan Bly (Cafe 24 Customer), Randall Batinkoff (Carol's Date), Jamie Kennedy (Street Hustler), Justin Herwick (Street Hustler), Maya Rudolph (Policewoman), John F. O'Donohue (Detective Ray), Dr. David A. Kipper (Hospital Doctor), Mary Elizabeth Still (Nurse Receptionist), Chloe Brooks (Child at Cafe 24), Cooper Brooks (Child at Cafe 24), Sharon L. Alexander (Female Passerby), Holly Denys (Female Passerby) and others.

Mark Andrus (Screenplay), James L. Brooks (Screenplay), Ray Quiroz (Script Supervisor), Walter Scott (Stunt Coordinator), Owen Wilson (Associate Producer), John Bailey (Director of Photography), Richard Marks (Editor) more..., Francine Maisler (Casting), Bill Brzeski (Production Design), Philip Toolin (Art Direction), Clay A. Griffith (Set Decoration), Carrie Angland (Makeup Artist), Susan Perlman (Other), Karen E. Etcoff (Casting), Julie Ansell (Thanks), Michael Besman (Thanks), Bruce Fowler (Orchestrator), Gena Bleier (Assistant Editor), Ralph Nelson Jr. (Still Photographer), Chester E. Tripp III (Stunts), Greg Addison (Lighting Technician), Mark Andrus (Story), Dennis Drummond (Supervising Sound Editor), BJ Davis (Stunt Double), Julia Davis (Stunt Coordinator), Julia Davis (Stunt Double), Hilary Schroeder (Assistant Editor), Denise Lynne Roberts (Stunts), Barbara Harris (ADR Voice Casting), Pablo Ferro (Title Designer), Tim McGovern (Visual Effects Supervisor), Mark Wade (Property Master), Armen Ksajikian (Musician), Richard Marks (Co-Producer), Aldric La'Auli Porter (Associate Producer), Aldric La'Auli Porter (First Assistant Director), Laura Ziskin (Executive Producer), William M. Connor (Second Assistant Director), Kristi Zea (Producer), Laurence Mark (Executive Producer) and others.