Tom Hanks (Robert Langdon), Ewan McGregor (Camerlengo Patrick McKenna), Ayelet Zurer (Vittoria Vetra), Stellan Skarsgård (Commander Richter), Pierfrancesco Favino (Inspector Olivetti), Nikolaj Lie Kaas (Assassin), Armin Mueller-Stahl (Cardinal Strauss) more..., Thure Lindhardt (Chartrand), David Pasquesi (Claudio Vincenzi), Cosimo Fusco (Father Simeon), Victor Alfieri (Lieutenant Valenti), Franklin Amobi (Cardinal Lamasse), Curt Lowens (Cardinal Ebner), Bob Yerkes (Cardinal Guidera), Marc Fiorini (Cardinal Baggia), Carmen Argenziano (Father Silvano Bentivoglio), Howard Mungo (Cardinal Yoruba), Rance Howard (Cardinal Beck), Steve Franken (Cardinal Colbert), Gino Conforti (Cardinal Pugini), Elya Baskin (Cardinal Petrov), Richard Rosetti (Conclave Cardinal), Silvano Marchetto (Conclave Cardinal), Thomas Morris (Urs Weber), Jonas Fisch (Adrian Bachman), August Wittgenstein (Swiss Guardsman), Ben Bela Böhm (Swiss Guardsman), Paul Schmitz (Swiss Guardsman), Jeffrey Boehm (Swiss Guard Blue), Xavier J. Nathan (Philippe), Steve Kehela (American Reporter), Ursula Brooks (BBC Reporter), Rashmi (British Reporter), Yan Cui (Chinese Reporter), Fritz Michel (French Reporter), Maria Cristina Heller (Italian Reporter), Rafael Petardi (Italian Reporter), Yesenia Adame (Mexican Reporter), Kristof Konrad (Polish Reporter), Masasa Moyo (South African Reporter) and others.

Akiva Goldsman (Screenplay), Brian Grazer (Producer), Dan Brown (Novel), John Calley (Producer), William M. Connor (Producer), Anna Culp (Producer), Ron Howard (Producer) more..., Kathleen McGill (Producer), Louisa Velis (Producer), Ute Leonhardt (Line Producer), Dan Brown (Executive Producer), Todd Hallowell (Executive Producer), Marco Valerio Pugini (Executive Producer), Hans Zimmer (Original Music Composer), Salvatore Totino (Director of Photography), Daniel P. Hanley (Editor), Mike Hill (Editor), David Koepp (Screenplay), Janet Hirshenson (Casting), Michelle Lewitt (Casting), Allan Cameron (Production Design), Alex Cameron (Art Direction), Keith P. Cunningham (Art Direction), Luke Freeborn (Art Direction), Marc Homes (Art Direction), Giles Masters (Art Direction), Dawn Swiderski (Art Direction), Larry Bellantoni (Set Decoration), Robert Gould (Set Decoration), Daniel Orlandi (Costume Design), John Blake (Makeup Department Head), Augusto Grassi (Costume Supervisor), Béatrice Kruger (Casting), Debbie McWilliams (Casting), Helen Monaghan (Costume Supervisor), Jane Jenkins (Casting), Luca Fortunato Asquini (Production Manager), Candice Muriedas (Art Department Coordinator), Heather Noble (Art Department Coordinator), Patricia Johnson (Assistant Art Director) and others.